Bulk Inquiry
YS 49
- Parent CAS: 132836-11-4
- Soluble in DMSO
- MF: C20H19NO2.HBr
- MW: 386.28
Description
More Information
| Parent CAS No. | 132836-11-4 |
|---|---|
| Chemical Name | 1-(naphthalen-1-ylmethyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol hydrobromide |
| SMILES | C1C=C2C(CC3C4=CC(O)=C(O)C=C4CCN3)=CC=CC2=CC=1.Br |
| MFCD | N.A. |
| InChi | InChI=1S/C20H19NO2.BrH/c22-19-11-15-8-9-21-18(17(15)12-20(19)23)10-14-6-3-5-13-4-1-2-7-16(13)14;/h1-7,11-12,18,21-23H,8-10H2;1H |
| InChiKey | JXFRKNGQHAAJKY-UHFFFAOYSA-N |
| CID | 10249534 |
| Short Description | Antiplatelet, antithrombotic |
References
- HS Yun-Choi et al. Antithrombotic Effects of YS-49 and YS-51—1-Naphthylmethyl Analogs of Higenamine. Thromb. Res. 2001, 104(4), 249-255.
- MK Pyo et al. Effects of two tetrahydroisoquinolines (YS-49 and YS-51) on experimental disseminated intravascular coagulation induced by lipopolysaccharide in rats. Arzneimittelforschung. 2004, 54(11), 705-10.
- K Tsoyi et al. HO-1 and JAK-2/STAT-1 signals are involved in preferential inhibition of iNOS over COX-2 gene expression by newly synthesized tetrahydroisoquinoline alkaloid, CKD712, in cells (...). Cell Signal. 2008, 20, 1839-47.
- JJ Sun, et al, YS-49, 1-(a-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, regulates angiotensin II-stimulated ROS production, JNK phosphorylation and vascular smooth muscle cell proliferation (...). Life Sci. 2008, 82, 600-607.
- M. K. Pyo et al. Effects of higenamine and its 1-nahthyl analogs, YS-49 and YS-51, on platelet TXA2 synthesis and aggregation, Thromb. Res. 2007, 120, 81-86.
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