Uprosertib
- GSK2141795 - GSK795
- Optical Purity: 100% e.e.
- Soluble in DMSO
- MF: C18H16Cl2F2N4O2
- MW: 429.25
Description
Uprosertib is an orally bioavailable, selective and ATP-competitive pan-Akt (PKB) inhibitor, potently inhibiting Akt 1, 2, 3, and Akt 1 E17K mutation with IC50s of 0.066 nM, 2 nM, 1.4 nM, 1.5 nM, and 0.2nM, respectively.
More Information
| Parent CAS No. | 1047634-65-0 |
|---|---|
| Chemical Name | N-((S)-1-Amino-3-(3,4-difluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)furan-2-carboxamide |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C1(C[C@@]([H])(CN)NC(=O)C2=CC(C3N(C)N=CC=3Cl)=C(Cl)O2)C=C(F)C(F)=CC=1 |&1:2,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C18H16Cl2F2N4O2/c1-26-16(12(19)8-24-26)11-6-15(28-17(11)20)18(27)25-10(7-23)4-9-2-3-13(21)14(22)5-9/h2-3,5-6,8,10H,4,7,23H2,1H3,(H,25,27)/t10-/m0/s1 |
| InChiKey | AXTAPYRUEKNRBA-JTQLQIEISA-N |
| CID | 51042438 |
| Short Description | Akt inhibitor |
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