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AT 13148 dihydrochloride
- Parent CAS: 1056901-62-2
- Soluble in DMSO
- MF: C17H16ClN3O.2HCl
- MW: 386.7
Description
AT 13148 dihydrochloride is an oral ATP-competitive multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity. Reported IC50 values include 38, 402 and 50 nM for AKT1, AKT2 and AKT3, 8 nM for p70S6K, 3 nM for PKA, 6 and 4 nM for ROCK1/2 and 63 nM for SGK3.
AGC kinases regulate survival, growth, cytoskeletal organization and therapy resistance. AT 13148 is relevant for profiling combined blockade of AKT, S6K, PKA, ROCK and SGK signaling in oncology models.
Key Features
- ATP-competitive multi-AGC kinase inhibitor
- Targets AKT, S6K, PKA, ROCK and SGK pathways
- Orally active antitumor pharmacology reported
- Distinct mechanism from allosteric AKT inhibitors
Applications
- AGC kinase pathway profiling
- Cancer cell survival assays
- AKT/S6K signaling studies
- Antitumor pharmacodynamic model research
More Information
| Parent CAS No. | 1056901-62-2 |
|---|---|
| Chemical Name | (S)-1-(4-(1H-pyrazol-4-yl)phenyl)-2-amino-1-(4-chlorophenyl)ethanol dihydrochloride |
| MFCD | N.A. |
| Short Description | AGC inhibitor |
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