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GSK 650394
Axon 1570
CAS:
890842-28-1
Purity:
99%
- Soluble in DMSO
- MF: C25H22N2O2
- MW: 382.45
Description
GSK 650394 is a specific inhibitor of serum- and glucocorticoid-regulated kinases with reported IC50 values of 62 nM for SGK1 and 103 nM for SGK2.
SGK kinases regulate ion transport, cell survival, stress responses and PI3K-dependent signaling outputs. GSK 650394 is a useful tool for studying SGK-dependent phosphorylation events and separating SGK biology from related AKT pathway effects.
Key Features
- Inhibitor of SGK1 and SGK2 kinases
- Reported IC50: 62 nM for SGK1 and 103 nM for SGK2
- Tool for studying PI3K-linked survival and ion-transport signaling
- Useful for dissecting SGK versus AKT pathway contributions
Applications
- SGK kinase assays
- Ion transport and renal signaling studies
- Cancer cell survival research
- PI3K downstream pathway analysis
More Information
| Parent CAS No. | 890842-28-1 |
|---|---|
| Chemical Name | 2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-benzoic acid |
| SMILES | C1N=C2NC=C(C3C=CC(C(=O)O)=C(C4CCCC4)C=3)C2=CC=1C1C=CC=CC=1 |
| MFCD | MFCD12828779 |
| InChi | InChI=1S/C25H22N2O2/c28-25(29)20-11-10-18(12-21(20)17-8-4-5-9-17)23-15-27-24-22(23)13-19(14-26-24)16-6-2-1-3-7-16/h1-3,6-7,10-15,17H,4-5,8-9H2,(H,26,27)(H,28,29) |
| InChiKey | WVSBGSNVCDAMCF-UHFFFAOYSA-N |
| CID | 25022668 |
| Short Description | SGK1 inhibitor |
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