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PF 4708671
- PF 04708671
- Soluble in DMSO
- MF: C19H21F3N6
- MW: 390.41
Description
PF 4708671 is a highly specific, cell-permeable S6K1 inhibitor with reported Ki value of 20 nM and IC50 value of 160 nM.
S6K1 is a downstream effector of mTORC1 that regulates protein synthesis, cell growth and metabolic signaling. PF 4708671 is useful for isolating S6K1-dependent outputs without directly inhibiting the closely related RSK or MSK kinase families.
Key Features
- Selective inhibitor of S6K1/p70 ribosomal S6 kinase
- Reported Ki: 20 nM and IC50: 160 nM
- Cell-permeable tool for mTOR downstream signaling studies
- Limited activity against related RSK and MSK kinases
Applications
- S6K1 kinase assays
- mTORC1 downstream pathway research
- Protein synthesis and cell growth studies
- Kinase selectivity profiling
More Information
| Parent CAS No. | 1255517-76-0 |
|---|---|
| Chemical Name | 2-((4-(5-ethylpyrimidin-4-yl)piperazin-1-yl)methyl)-5-(trifluoromethyl)-1H-benzo[d]imidazole |
| extra_info | . |
| SMILES | C1C(CC)=C(N2CCN(CC3=NC4C=C(C(F)(F)F)C=CC=4N3)CC2)N=CN=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C19H21F3N6/c1-2-13-10-23-12-24-18(13)28-7-5-27(6-8-28)11-17-25-15-4-3-14(19(20,21)22)9-16(15)26-17/h3-4,9-10,12H,2,5-8,11H2,1H3,(H,25,26) |
| InChiKey | FBLPQCAQRNSVHB-UHFFFAOYSA-N |
| CID | 51371303 |
| Short Description | S6K1 inhibitor |
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