The p70 ribosomal S6 kinases (S6K) and p90 ribosomal S6 kinases (RSK) are distinct families of Ser/Thr kinases (EC that regulate diverse cellular processes by phosphorylation of ribosomal protein S6 (Rps6). They transduces anabolic signals that indicate nutritional status to regulate cell size and growth and metabolism through various mechanisms. These include effects on the translational machinery and on cellular energy levels through the activity of adenosine monophosphate (AMP)-activated protein kinase (AMPK)[1].
RSKs are downstream effectors of the Ras–extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) signaling cascade, and IGF-1 (IIS) and mTOR signaling pathways[2]. RSK phosphorylates a variety of proteins, including transcription factors, immediate-early gene products, translational regulators, enzymes, and structural proteins, that potentially link it to many biological processes such as cell proliferation, cell differentiation, and survival. The ribosomal protein S6 kinase 1 (S6K1) is one of two mammalian p70-RSK proteins, acting as a downstream mediator of mammalian target of rapamycin (mTOR) in the phosphoinositide 3-kinase (PI3K) pathway and/or the Ras-MAPK pathway. It acts to converge growth factor, hormonal, nutrient and energy signals in order to maintain cellular homeostasis[3]. It has been hypothesized that the mTORC1-S6K1 is a master determinant in longevity control[4].

RSK subclasses listed: p70-RSK, p90-RSK

[1] Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span. C. Selman et al. Science 2009, 326, 140-144.
[2] R. Anjum, J. Blenis. The RSK family of kinases: emerging roles in cellular signaling. Nat. Rev. Mol. Cell Biol, 2008, 9, 747-758.
[3] Y. Abe et al. p90 ribosomal S6 kinase and p70 ribosomal S6 kinase link phosphorylation of the eukaryotic chaperonin containing TCP-1 to growth factor, insulin, and nutrient signaling. J. Bio.l Chem. 2009, 284, 14939-14948.
[4] D.C.Bedford. S6K1: reducing the RiSKs of aging. Dis. Model. Mech. 2010, 3, 123-124.

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Axon ID Name Description From price
1903 DG2 RSK inhibitor (p70 ribosomal S6 kinase 1 specific) €95.00
2464 LY 2584702 tosylate Oral, selective ATP competitive inhibitor of p70 S6 kinase (S6K1) €125.00
1602 PF 4708671 RSK inhibitor (p70 RSK specific) €110.00

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