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AS 1892802
- Optical Purity: >99% e.e.
- Soluble in DMSO
- MF: C20H19N3O2
- MW: 333.38
Description
AS 1892802 is a potent, selective, ATP-competitive and orally active ROCK inhibitor with reported activity against ROCK1 and ROCK2. Published IC50 values include 122 nM for human ROCK1, 52 nM for human ROCK2 and 57 nM for rat ROCK2 in one profiling set.
ROCK kinases regulate actomyosin contractility, pain signaling, cartilage damage, inflammation and cancer cell motility. AS 1892802 is relevant for studying ROCK-dependent MLC2 phosphorylation and disease-associated cytoskeletal signaling.
Key Features
- ATP-competitive ROCK1/ROCK2 inhibitor
- Orally active pharmacology reported
- Reduces inflammatory and non-inflammatory pain responses
- Modulates MLC2 phosphorylation and osteoarthritis-associated pathways
Applications
- ROCK kinase assays
- Pain and inflammation model research
- Osteoarthritis cartilage studies
- Cancer cell motility and cytoskeletal signaling assays
More Information
| Parent CAS No. | 928320-12-1 |
|---|---|
| Chemical Name | (S)-1-(2-hydroxy-1-phenylethyl)-3-(4-(pyridin-4-yl)phenyl)urea |
| SMILES | N([C@@H](C1=CC=CC=C1)CO)C(NC1=CC=C(C2C=CN=CC=2)C=C1)=O |&1:1,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C20H19N3O2/c24-14-19(17-4-2-1-3-5-17)23-20(25)22-18-8-6-15(7-9-18)16-10-12-21-13-11-16/h1-13,19,24H,14H2,(H2,22,23,25)/t19-/m1/s1 |
| InChiKey | WDTFYYZHMRBVHK-LJQANCHMSA-N |
| CID | 46911016 |
| Short Description | ROCK inhibitor |
References
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