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Fasudil hydrochloride
- HA1077
- Parent CAS: 103745-39-7
- Soluble in water, DMSO and EtOH
- MF: C14H17N3O2S.HCl
- MW: 327.83
Description
Fasudil hydrochloride is an orally active ROCK inhibitor with a Ki value of 0.40 μM. Moreover, Fasudil is an intracellular calcium antagonist.
More Information
| Parent CAS No. | 103745-39-7 |
|---|---|
| Chemical Name | 5-(1,4-Diazepan-1-ylsulfonyl)isoquinoline hydrochloride |
| SMILES | C1NCCCN(S(=O)(=O)C2=CC=CC3C=NC=CC2=3)C1.Cl |
| MFCD | MFCD00943198 |
| InChi | InChI=1S/C14H17N3O2S.ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;/h1,3-5,7,11,15H,2,6,8-10H2;1H |
| InChiKey | LFVPBERIVUNMGV-UHFFFAOYSA-N |
| CID | 163751 |
| Short Description | ROCK inhibitor |
References
- JK Liao et al. Rho kinase (ROCK) inhibitors. J Cardiovasc Pharmacol. 2007 Jul;50(1):17-24.
- T Asano et al. New pharmacological strategies in vascular diseases: a novel intracellular calcium antagonist, HA1077 (AT-877) and cerebral vasospasm. Methods Find Exp Clin Pharmacol. 1990 Jul-Aug;12(6):443-8.
- M Chen et al. Fasudil and its analogs: a new powerful weapon in the long war against central nervous system disorders? Expert Opin Investig Drugs. 2013 Apr;22(4):537-50.
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