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Z944
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C19H27ClFN3O2
- MW: 383.89
Description
Z944 is a highly selective, orally available T-type Ca2+ channel blocker with IC50 values of 50 to 160 nM for hCa V 3.1, hCa V 3.2, and hCa V 3.3 T types. Upon administration to GAERS animals, Z944 potently suppressed absence seizures by 85 to 90% via a mechanism distinct from the effects of ethosuximide and valproate.
More Information
| Parent CAS No. | 1199236-64-0 |
|---|---|
| Chemical Name | N-((1-(2-(tert-Butylamino)-2-oxoethyl)piperidin-4-yl)methyl)-3-chloro-5-fluorobenzamide |
| SMILES | C1C(F)=CC(Cl)=CC=1C(=O)NCC1CCN(CC(NC(C)(C)C)=O)CC1 |
| MFCD | N.A. |
| InChi | InChI=1S/C19H27ClFN3O2/c1-19(2,3)23-17(25)12-24-6-4-13(5-7-24)11-22-18(26)14-8-15(20)10-16(21)9-14/h8-10,13H,4-7,11-12H2,1-3H3,(H,22,26)(H,23,25) |
| InChiKey | JOCLITFYIMJMNK-UHFFFAOYSA-N |
| CID | 44540045 |
| Short Description | Ca channel blocker |
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