Calcium
Calcium channels have long been the target of therapeutic drugs aimed at treating the symptoms of cardiovascular disease and migraine headache. They regulate the permeability of the cell membrane towards calcium. Axon Medchem offers pharmacological standards that interact at each of the 2 main classes within the family of calcium channels, the voltage-gated, and the ligand-gated channels.[1].
[1] InternationalUnion of Pharmacology. XLVIII. Nomenclature and Structure-Function Relationships of Voltage-Gated Calcium Channels. WA Catterall, E Perez-Reyes, TP Snutch, J Striessnig. Pharmacol Rev 57:411–425, 2005
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 1758 | (R)-(+)-BAY K 8644 | Calcium (Ca2+) channel modulator | €115.00 | |
| 1759 | (S)-(-)-BAY K 8644 | Calcium (Ca2+) channel activator (L-type voltage-gated) | €115.00 | |
| 3785 | ABT-639 | Peripherally acting, selective and orally bioavailable T-type Ca2+ channel blocker | €115.00 | |
| 3015 | Amlodipine besylate | Ca2+ channel blocker | €90.00 | |
| 3013 | Aranidipine | Ca2+ channel antagonist | €110.00 | |
| 3160 | Azelnidipine | Calcium channel blocker | €70.00 | |
| 3014 | Barnidipine hydrochloride | Potent Ca2+ channel blocker (L-type voltage gated) | €105.00 | |
| 1697 | BAY K 8644 | Calcium (Ca2+) channel activator (L-type voltage-gated) | €95.00 | |
| 3131 | Benidipine hydrochloride | Ca2+ channel blocker | €70.00 | |
| 1868 | CRAC inhibitor 44 | Potent and selective CRAC ion channel blocker | €110.00 | |
| 3323 | Diltiazem hydrochloride | Ca2+ channel antagonist (L-type voltage gated) | €50.00 | |
| 3450 | Dronedarone hydrochloride | Ca2+/K+/Na+ channel blocker; Antiarrhythmic agent | €100.00 | |
| 2952 | Fantofarone | Highly potent and specific Ca2+ channel antagonist | €125.00 | |
| 3848 | Fasudil hydrochloride | Orally active ROCK inhibitor; Ca2+ channel antagonist | €50.00 | |
| 1448 | Felodipine | Ca2+ channel blocker | €65.00 | |
| 3501 | Isradipine | Ca2+ channel antagonist | €60.00 | |
| 3185 | L651582 | Ca2+ channel blocker | €120.00 | |
| 3640 | Loperamide hydrochloride | Potent Mu-opioid agonist | €50.00 | |
| 3254 | Nicardipine | Ca2+ channel antagonist | €50.00 | |
| 2068 | Nifedipine | Ca2+ channel blocker (L-type voltage gated) | €55.00 | |
| 3158 | Otilonium bromide | Ca2+ channel blocker | €70.00 | |
| 3887 | Pinaverium bromide | Ca2+ channel blocker (L-type voltage gated) | €70.00 | |
| 1823 | Pregabalin | Reduces synaptic signaling by binding to α2δ subunits | €85.00 | |
| 3644 | Propafenone hydrochloride | Ca2+/K+/Na+ channel blocker; Antiarrhythmic agent | €60.00 | |
| 3507 | Ranolazine | Ca2+/K+/Na+ channel blocker; Anti-anginal agent | €70.00 | |
| 1221 | SKF 96365 hydrochloride | Ca2+ channel blocker | €105.00 | |
| 3452 | Verapamil hydrochloride | Ca2+ channel antagonist | €50.00 | |
| 3025 | Z944 | Highly selective, orally available Ca2+ channel blocker (T-type voltage gated) | €130.00 | |