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Pregabalin
- PD144723
- Optical Purity: Optically pure
- Soluble in water
- MF: C8H17NO2
- MW: 159.23
Description
Pregabalin (PD144723) is a GABA analogue that binds the α2δ auxiliary subunit of voltage-gated calcium channels rather than acting directly at GABA receptors.
Binding to α2δ subunits reduces excitatory neurotransmitter release in the central nervous system and underlies pregabalin's relevance to neuropathic pain, epilepsy and anxiety-related pharmacology. It is used as a reference ligand for calcium-channel α2δ biology.
Key Features
- α2δ calcium-channel auxiliary subunit ligand
- Does not directly activate GABA receptors
- Reduces presynaptic release of excitatory neurotransmitters
- Clinically relevant CNS pharmacology reference compound
Applications
- Voltage-gated calcium-channel α2δ studies
- Neuropathic pain and neuronal excitability models
- Synaptic neurotransmitter release assays
- CNS drug-mechanism research
More Information
| Parent CAS No. | 148553-50-8 |
|---|---|
| Chemical Name | (S)-3-(aminomethyl)-5-methylhexanoic acid |
| SMILES | C(O)(=O)C[C@@H](CN)CC(C)C |&1:4,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C8H17NO2/c1-6(2)3-7(5-9)4-8(10)11/h6-7H,3-5,9H2,1-2H3,(H,10,11)/t7-/m0/s1 |
| InChiKey | AYXYPKUFHZROOJ-ZETCQYMHSA-N |
| CID | 5486971 |
| Short Description | Ca Channel modulator |
References
- CP Taylor et al. Pharmacology and mechanism of action of pregabalin: The calcium channel α2–δ (alpha2–delta) subunit as a target for antiepileptic drug discovery. Epilepsy Res. 2007, 73, 137–150.
- Y Zhang et al. Development and validation of a direct enantiomeric separation of pregabalin to support isolated perfused rat kidney studies. J. Chrom. B. 2008, 875, 148–153.
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