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Felodipine
- Soluble in DMSO
- MF: C18H19Cl2NO4
- MW: 384.25
Description
Felodipine is a dihydropyridine L-type calcium channel blocker with pronounced activity on vascular smooth muscle.
Felodipine inhibits CaV1.2-mediated calcium entry, producing arterial vasodilation and reduced peripheral resistance. It is a clinically established reference for cardiovascular calcium-channel pharmacology, vascular tone and excitation–contraction coupling.
Key Features
- Dihydropyridine L-type calcium channel blocker
- Preferential vascular smooth-muscle activity
- Reduces calcium-dependent arterial contraction
- Clinically established antihypertensive pharmacology
Applications
- L-type calcium channel assays
- Vascular smooth-muscle contraction studies
- Hypertension and vasodilation models
- Calcium-dependent excitation–contraction research
More Information
| Parent CAS No. | 72509-76-3 |
|---|---|
| Chemical Name | 3,5-pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, 3-ethyl-5-methylester |
| SMILES | C1(C)=C(C(OCC)=O)C(C2C(Cl)=C(Cl)C=CC=2)C(C(=O)OC)=C(C)N1 |
| MFCD | MFCD00868316 |
| InChi | InChI=1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3 |
| InChiKey | RZTAMFZIAATZDJ-UHFFFAOYSA-N |
| CID | 3333 |
| Short Description | Ca channel blocker |
References
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