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KN 93 phosphate
- Parent CAS: 1188890-40-5
- Soluble in water and DMSO
- MF: C26H29ClN2O4S.H3PO4
- MW: 599.03
Description
Inhibitor of multifunctional Ca2+/Calmodulin-dependent protein kinase (CaMKII; Ki value 0.37 μM for inhibition of CaMKII phosphorylating activity). In addition, KN93 also affects CaV1.3 and CaV1.2 calcium channels in a CaMKII-independent manner.
The parent molecule KN 93 (Axon 2566) is available as well.
More Information
| Parent CAS No. | 1188890-40-5 |
|---|---|
| Chemical Name | (E)-N-(2-(((3-(4-chlorophenyl)allyl)(methyl)amino)methyl)phenyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide phosphate |
| SMILES | C1(S(N(C2=CC=CC=C2CN(C/C=C/C2=CC=C(Cl)C=C2)C)CCO)(=O)=O)=CC=C(OC)C=C1.P(O)(O)(O)=O |
| MFCD | MFCD03788201 |
| InChi | InChI=1S/C26H29ClN2O4S.H3O4P/c1-28(17-5-6-21-9-11-23(27)12-10-21)20-22-7-3-4-8-26(22)29(18-19-30)34(31,32)25-15-13-24(33-2)14-16-25;1-5(2,3)4/h3-16,30H,17-20H2,1-2H3;(H3,1,2,3,4)/b6-5+; |
| InChiKey | NNKJTPOXLIILMB-IPZCTEOASA-N |
| CID | 16760530 |
| Short Description | CaMKII inhibitor |
References
- M Sumi et al. The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells. Biochem Biophys Res Commun. 1991 Dec 31;181(3):968-75.
- ME Anderson et al. KN-93, an inhibitor of multifunctional Ca++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart. J Pharmacol Exp Ther. 1998 Dec;287(3):996-1006.
- L Gao et al. CaMKII-independent effects of KN93 and its inactive analog KN92: reversible inhibition of L-type calcium channels. Biochem Biophys Res Commun. 2006 Jul 14;345(4):1606-10.
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