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KN 93
- Soluble in DMSO
- MF: C26H29ClN2O4S
- MW: 501.04
Description
KN 93 is an inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII). It suppresses CaMKII-dependent phosphorylation while also showing reported effects on voltage-gated calcium channels, which should be considered in experimental interpretation.
CaMKII integrates calcium/calmodulin signals to regulate synaptic plasticity, cardiac excitation-contraction coupling, ion-channel phosphorylation and cell signaling. KN 93 is a common tool for studying CaMKII-dependent pathways in neuronal and cardiovascular models.
Key Features
- CaMKII inhibitor
- Reported Ki: 0.37 µM for CaMKII phosphorylating activity
- Suppresses calcium/calmodulin-dependent kinase signaling
- Reported off-target effects at CaV1.3 and CaV1.2 channels should be considered
Applications
- CaMKII kinase pharmacology
- Calcium signaling and phosphorylation assays
- Synaptic plasticity and neuronal signaling studies
- Cardiac excitation-contraction coupling research
The water-soluble salt, KN 93 phosphate (Axon 2555) is available as well.
More Information
| Parent CAS No. | 1188890-40-5 |
|---|---|
| Chemical Name | (E)-N-(2-(((3-(4-chlorophenyl)allyl)(methyl)amino)methyl)phenyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide |
| SMILES | C1(S(N(C2=CC=CC=C2CN(C/C=C/C2=CC=C(Cl)C=C2)C)CCO)(=O)=O)=CC=C(OC)C=C1 |
| MFCD | MFCD03788201 |
| InChi | InChI=1S/C26H29ClN2O4S/c1-28(17-5-6-21-9-11-23(27)12-10-21)20-22-7-3-4-8-26(22)29(18-19-30)34(31,32)25-15-13-24(33-2)14-16-25/h3-16,30H,17-20H2,1-2H3/b6-5+ |
| InChiKey | LLLQTDSSHZREGW-AATRIKPKSA-N |
| CID | 5312122 |
| Short Description | CaMKII inhibitor |
References
- M Sumi et al. The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells. Biochem Biophys Res Commun. 1991 Dec 31;181(3):968-75.
- ME Anderson et al. KN-93, an inhibitor of multifunctional Ca++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart. J Pharmacol Exp Ther. 1998 Dec;287(3):996-1006.
- L Gao et al. CaMKII-independent effects of KN93 and its inactive analog KN92: reversible inhibition of L-type calcium channels. Biochem Biophys Res Commun. 2006 Jul 14;345(4):1606-10.
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