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Nifedipine
- Soluble in DMSO
- MF: C17H18N2O6
- MW: 346.33
Description
More Information
| Parent CAS No. | 21829-25-4 |
|---|---|
| Chemical Name | dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate |
| extra_info | . |
| SMILES | C1(C(OC)=O)C(C2C=CC=CC=2[N+]([O-])=O)C(C(=O)OC)=C(C)NC=1C |
| MFCD | MFCD00057326 |
| InChi | InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3 |
| InChiKey | HYIMSNHJOBLJNT-UHFFFAOYSA-N |
| CID | 4485 |
| Short Description | Ca channel blocker |
References
- MJ Brown et al. Morbidity and mortality in patients randomised to double-blind treatment with a long-acting calcium-channel blocker or diuretic in the International Nifedipine GITS study: Intervention as (...). The Lancet, 2000, 356(9227), 366-372.
- JH Weiss et al. The calcium channel blocker nifedipine attenuates slow excitatory amino acid neurotoxicity. Science, 1990, 247(4949), 1474-1477.
- E Braunwald. Mechanism of action of calcium-channel-blocking agents. N. Engl. J. Med, 1982, 307(26), 1618.
- W Vater et al. Pharmacology of 4-(2'-nitrophenyl)-2, 6-dimethyl-1, 4-dihydropyridine-3, 5-dicarboxylic acid dimethyl ester (Nifedipine, BAY a 1040). Arzneimittel-Forschung, 1972, 22(1), 1-14.
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