ROCK

Rho-kinase (EC 2.7.11.1) is a serine/threonine kinase belonging to the AGC-family of protein kinases, originally identified as the first downstream effector of the small GTPase Rho. There are two Rho-kinase members, Rho-kinase α/ROCK2/ROKα and Rho-kinase β/ROCK1/ROKβ; both Rho-kinases are composed of an N-terminal catalytic domain, a central coiled-coil domain, and a C-terminal PH domain interrupted by a Cys-rich region. Rho-family small GTPases, such as Rho, Rac, and Cdc42, mediate a broad range of cellular responses that involve the actin cytoskeleton. Rhoregulates stress fiber formation and cell contraction, whereas Rac and Cdc42 regulate the formation of lamellipodia and filopodia, respectively, and promote protrusive activities. Rho-family GTPases also modulate microtubule dynamics and cell polarity. Furthermore, Rho-kinase is involved in smooth muscle contraction and actin organization, cell migration, neuronal architecture and neurite elongation, and cytokenesis, among several other functions[1],[2].


[1] Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity. M. Amano, M. Nakayama, K. Kaibuchi. Cytoskeleton 2013, 67, 545-554.
[2]Rho Kinase (ROCK) Inhibitors. J.K. Liao, M. Seto, K. Noma. J. Cardiovasc. Pharmacol. 2007, 50, 17-24.

9 Item(s)

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Axon ID Name Description From price
2187 AS 1892802 Potent, selective, ATP-competitive ROCK inhibitor €95.00
2166 AT 13148 dihydrochloride ATP-competitive inhibitor of multi-AGC kinases €85.00
1167 GSK 269962A ROCK1 and ROCK2 inhibitor €75.00
5011 Naive Stem Cell 5i inhibitor Set Set of five inhibitors for the induction and maintenance of human naive stem cell pluripotency €240.00
5010 Naive Stem Cell NHSM inhibitor Set Set of inhibitors for isolation, generation, derivatization and stabilization of naive hPSCs €275.00
2229 RKI 1447 Potent inhibitor of the Rho-associated ROCK kinases €105.00
5009 Stem Cell 4i inhibitor Set Set of Thiazovivin, SB 431542, PD 0325901, and CHIR 99021 (inhibitors of ROCK, TGF-β, MEK, and GSK-3 resp.) €200.00
1535 Thiazovivin ROCK inhibitor and iPSC stimulator; Stem cell related €95.00
1683 Y 27632 dihydrochloride ROCK1 and ROCK2 inhibitor €65.00

9 Item(s)

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