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Thiazovivin
- TZV
- Soluble in DMSO
- MF: C15H13N5OS
- MW: 311.36
Description
Thiazovivin is a small-molecule ROCK pathway inhibitor that enhances survival of dissociated human embryonic stem cells and induced pluripotent stem cells.
Rho/ROCK signaling regulates actomyosin contractility, adhesion stress and dissociation-induced apoptosis in pluripotent cells. The combination of ROCK inhibitor Thiazovivin, ALK5 inhibitor SB431542 (Axon 1661), MEK inhibitor PD0325901 (Axon 1408), and GSK3 inhibitor CHIR99021 (Axon 1386) forms a widely used, powerful chemical cocktail in stem cell biology, namely Stem Cell 4i inhibitor Set (Axon 5009), which is primarily utilized to dramatically increase the efficiency of reprogramming somatic cells (like fibroblasts) into induced pluripotent stem cells (iPSCs) and to promote the survival and self-renewal of human pluripotent stem cells.
Key Features
- ROCK pathway inhibitor for stem cell research
- Improves survival of dissociated pluripotent stem cells
- Modulates cytoskeletal tension and adhesion-associated stress
- Supports maintenance of hESC and iPSC cultures
Applications
- Stem cell culture and passaging
- Cellular reprogramming protocols
- Rho/ROCK signaling studies
- Pluripotent cell survival assays
Promotion: Thiazovivin is also part of Inhibitor Set(s): Stem Cell 4i inhibitor Set (Axon 5009)
More Information
| Parent CAS No. | 1226056-71-8 |
|---|---|
| Chemical Name | N-benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamide |
| SMILES | C1C=C(NC2=NC(C(=O)NCC3C=CC=CC=3)=CS2)N=CN=1 |
| MFCD | MFCD16495823 |
| InChi | InChI=1S/C15H13N5OS/c21-14(17-8-11-4-2-1-3-5-11)12-9-22-15(19-12)20-13-6-7-16-10-18-13/h1-7,9-10H,8H2,(H,17,21)(H,16,18,19,20) |
| InChiKey | DOBKQCZBPPCLEG-UHFFFAOYSA-N |
| CID | 46209426 |
| Short Description | ROCK inhibitor; hESC enhancer |
References
- T Lin and S Ding et al. A chemical platform for improved induction of human iPSCs. Nat. Methods. 2009, 6(11), 805-8.
- Y Xu and S Ding et al. Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proc. Natl. Acad. Sci. USA 2010, 107, 8129.
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