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RepSox
- E616452 - SJN2511
Axon 4385
CAS:
446859-33-2
Purity:
99%
- Soluble in DMSO and EtOH
- MF: C17H13N5
- MW: 287.32
Description
RepSox is a potent and selective TGF-βR 1 inhibitor with IC50 values of 23 nM and 4 nM for ALK5 binding and ALK5 autophosphorylation, respectively.
More Information
| Parent CAS No. | 446859-33-2 |
|---|---|
| Chemical Name | 4-(1,5-Diaza-2-naphthyl)-3-(6-methyl-2-pyridyl)pyrazole |
| SMILES | N1N=C(C2=NC(C)=CC=C2)C(C2=CC=C3N=CC=CC3=N2)=C1 |
| MFCD | MFCD09037561 |
| InChi | InChI=1S/C17H13N5/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15(21-13)6-3-9-18-14/h2-10H,1H3,(H,19,22) |
| InChiKey | LBPKYPYHDKKRFS-UHFFFAOYSA-N |
| CID | 449054 |
| Short Description | ALK5 inhibitor |
References
- F Gellibert et al. Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-beta type I receptor inhibitors. J Med Chem. 2004 Aug 26;47(18):4494-506.
- JK Ichida et al. A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog. Cell Stem Cell. 2009 Nov 6;5(5):491-503.
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