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SB 505124
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C20H21N3O2
- MW: 335.4
Description
SB 505124 is a selective inhibitor of TGF-β type I receptors ALK5 and ALK4, with reported IC50 values of 47 nM and 129 nM respectively, and also inhibits ALK7. It blocks TGF-β/activin-induced SMAD2 signaling while sparing BMP-induced SMAD1/5/8 signaling.
TGF-β and activin pathways regulate fibrosis, epithelial plasticity, apoptosis, immune suppression and differentiation. SB 505124 is relevant for distinguishing ALK4/5/7 signaling from BMP receptor pathways in cellular disease models.
Key Features
- Selective ALK4 and ALK5 inhibitor
- Also inhibits the related ALK7 receptor
- Blocks TGF-β/activin-induced SMAD2 signaling
- Spares BMP-induced SMAD1/5/8 signaling
Applications
- TGF-β pathway studies
- Activin receptor signaling assays
- Fibrosis and EMT model research
- SMAD and MAPK pathway cross-talk profiling
More Information
| Parent CAS No. | 694433-59-5 |
|---|---|
| Chemical Name | 2-(4-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl)-6-methylpyridine |
| SMILES | C1(C2NC(C(C)(C)C)=NC=2C2=CC=C3OCOC3=C2)=NC(C)=CC=C1 |
| MFCD | MFCD20926329 |
| InChi | InChI=1S/C20H21N3O2/c1-12-6-5-7-14(21-12)18-17(22-19(23-18)20(2,3)4)13-8-9-15-16(10-13)25-11-24-15/h5-10H,11H2,1-4H3,(H,22,23) |
| InChiKey | WGZOTBUYUFBEPZ-UHFFFAOYSA-N |
| CID | 9858940 |
| Short Description | ALK5 inhibitor |
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