Bulk Inquiry
TJ191
- Soluble in DMSO
- MF: C13H21NO2S
- MW: 255.38
Description
TJ191 is a potent and selective anti-cancer molecule with pronounced activity against human malignant T-cells expressing low levels of TβRIII. TJ191 selectively inhibits the proliferation of, and induces apoptosis in, various T-cell-derived hematological malignant cell lines. TJ191 selectively targets certain cancer cells without affecting the proliferation of other cancer cells or normal fibroblasts or immune cells (over 600-fold selectivity).
More Information
| Parent CAS No. | 1522415-97-9 |
|---|---|
| Chemical Name | Methyl 2-amino-5-heptylthiophene-3-carboxylate |
| SMILES | C1(C(OC)=O)=C(N)SC(CCCCCCC)=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C13H21NO2S/c1-3-4-5-6-7-8-10-9-11(12(14)17-10)13(15)16-2/h9H,3-8,14H2,1-2H3 |
| InChiKey | HUFNXSPJUAHQHP-UHFFFAOYSA-N |
| CID | 72704992 |
| Short Description | Anticancer agent |
References
- A El-Gazzar et al. 2-Amino-3-methylcarboxy-5-heptyl-thiophene (TJ191) is a selective anti-cancer small molecule that targets low TβRIII-expressing malignant T-cell leukemia/lymphoma cells. Oncotarget. 2017 Dec 15;9(5):6259-6269.
- J Thomas et al. Pronounced anti-proliferative activity and tumor cell selectivity of 5-alkyl-2-amino-3-methylcarboxylate thiophenes. Eur J Med Chem. 2017 May 26;132:219-235.
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