Bulk Inquiry
A 77-01
- Soluble in DMSO
- MF: C18H14N4
- MW: 286.33
Description
A 77-01 is a potent TGF-β type I receptor/ALK5 inhibitor with an IC50 value of 25 nM.
ALK5 drives TGF-β-dependent SMAD2/3 phosphorylation, epithelial-to-mesenchymal transition and differentiation responses. A 77-01 is a close analogue and active degradation-related compound of A-83-01, with similar TGF-β pathway pharmacology.
Key Features
- Potent inhibitor of ALK5/TGFBR1
- IC50: 25 nM
- Close analogue of A-83-01 with similar biological profile
- Blocks TGF-β/SMAD pathway signaling
Applications
- TGF-β/ALK5 pathway research
- SMAD2/3 phosphorylation assays
- EMT and fibrosis-related models
- Stem cell differentiation and reprogramming studies
Note: A-83-01 is available as Axon 1421.
More Information
| Parent CAS No. | 607737-87-1 |
|---|---|
| Chemical Name | 4-(3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)quinoline |
| SMILES | C1C=C2C(C3=CNN=C3C3N=C(C)C=CC=3)=CC=NC2=CC=1 |
| MFCD | MFCD07367791 |
| InChi | InChI=1S/C18H14N4/c1-12-5-4-8-17(21-12)18-15(11-20-22-18)13-9-10-19-16-7-3-2-6-14(13)16/h2-11H,1H3,(H,20,22) |
| InChiKey | KJTYZDORHCDZPS-UHFFFAOYSA-N |
| CID | 10469233 |
| Short Description | ALK5 inhibitor |
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