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A 83-01
- Soluble in DMSO
- MF: C25H19N5S
- MW: 421.52
Description
Potent inhibitor of TGF-β type I receptor superfamily activin-like kinase ALK5 and its relatives ALK4 and ALK7 (IC50 to be 12, 45 and 7.5 nM respectively). A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-β, but had no effect on BMP signaling; Used to generate rat and human iPS cells towards a mouse ES cell like self-renewal state.
*Note: A 83-01 is found to decompose to A 77-01 (Axon 1744) in solution slowly. Hence freshly prepared solution is highly recommended and otherwise, its stock solution in DMSO needs to be stored <-20 °C (not longer than 1 month).
More Information
| Parent CAS No. | 909910-43-6 |
|---|---|
| Chemical Name | 3-(6-methylpyridin-2-yl)-N-phenyl-4-(quinolin-4-yl)-1H-pyrazole-1-carbothioamide |
| SMILES | C1C=C2C(C3=CN(C(NC4C=CC=CC=4)=S)N=C3C3N=C(C)C=CC=3)=CC=NC2=CC=1 |
| MFCD | MFCD08705403 |
| InChi | InChI=1S/C25H19N5S/c1-17-8-7-13-23(27-17)24-21(19-14-15-26-22-12-6-5-11-20(19)22)16-30(29-24)25(31)28-18-9-3-2-4-10-18/h2-16H,1H3,(H,28,31) |
| InChiKey | HIJMSZGHKQPPJS-UHFFFAOYSA-N |
| CID | 16218924 |
| Short Description | ALK5 inhibitor |
References
- M Tojo et al. The ALK5 inhibitor A-83-01 inhibits smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-β. Cancer. Sci. 2005, 96, 791-800.
- W. Li et al. Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors. Cell Stem Cell 2009, 4, 16-19.
- List of publications using A 83-01 (Axon 1421) purchased from Axon Medchem
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