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OAC2
Axon 2651
CAS:
6019-39-2
Purity:
100%
- Soluble in DMSO
- MF: C15H12N2O
- MW: 236.27
Description
Oct4- and Nanog-activating compound that enhances 4F-induced reprogramming efficiency and considerably accelerates the generation of iPSC formation. OAC2 is one component of a mix of compounds (9C) that can be used to generate cardiomyocyte-like cells from human fibroblasts.
More Information
| Parent CAS No. | 6019-39-2 |
|---|---|
| Chemical Name | N-(1H-Indol-5-yl)benzamide |
| SMILES | C1C=C(C(=O)NC2C=CC3NC=CC=3C=2)C=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C15H12N2O/c18-15(11-4-2-1-3-5-11)17-13-6-7-14-12(10-13)8-9-16-14/h1-10,16H,(H,17,18) |
| InChiKey | JCAFGYWSIWYMOX-UHFFFAOYSA-N |
| CID | 2814138 |
| Short Description | Oct4 activator |
References
- N Cao et al. Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science. 2016 Jun 3;352(6290):1216-20.
- W Li et al. Identification of Oct4-activating compounds that enhance reprogramming efficiency. Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):20853-8.
- H Yamakawa. Heart regeneration for clinical application update 2016: from induced pluripotent stem cells to direct cardiac reprogramming. Inflammation and Regeneration (2016) 36:23
- O Tsuji et al. Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury. Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12704-9.
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