Oct

The POU domain family of transcription factors (TF class 3.1.10.5) regulates developmental processes ranging from specification of the early embryo to terminal differentiation. About half of these factors display substantial affinity for an 8 bp DNA site termed the octamer motif, and are hence known as Oct proteins[1]. Oct4 (Pou5f1) is a well-known Oct factor, with varied and essential roles in development and a key regulator for ESC pluripotency. Reduced expression of Oct4 results in differentiation of ESCs into trophectodermal cells, and ovexpression of Oct4 leads to differentiation of ESCs along the mesodermal and primitive endodermal lineages[2].


[1] D Tantin et al. Oct transcription factors in development and stem cells: insights and mechanisms. Development. 2013 Jul;140(14):2857-66.
[2] W Li et al. Identification of Oct4-activating compounds that enhance reprogramming efficiency. Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):20853-8.

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Axon ID Name Description From price
4020 O4I4 Metabolically stable next-generation endogenous Oct4 inducer  Recently added €90.00
2651 OAC2 Oct4 and Nanog activating compound that enhances reprogramming efficiency €60.00

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