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JNJ 10191584
- Soluble in DMSO
- MF: C13H15ClN4O
- MW: 278.74
Description
JNJ 10191584 is a selective, orally active silent histamine H4 receptor antagonist.
H4 receptors regulate immune-cell trafficking, inflammatory mediator release and pruritic responses. JNJ 10191584 is useful for blocking H4 receptor signaling without inverse agonist bias in immunopharmacology studies.
Key Features
- Selective silent H4 receptor antagonist
- Orally active pharmacology profile
- Blocks histamine H4 receptor signaling
- Relevant to immune-cell chemotaxis and inflammation research
Applications
- H4 receptor functional assays
- Inflammation and pruritus pathway studies
- Immune cell migration research
- Histamine receptor antagonist profiling
More Information
| Parent CAS No. | 73903-17-0 |
|---|---|
| Chemical Name | (6-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperazin-1-yl)-methanone |
| SMILES | C1C=C2N=C(C(=O)N3CCN(C)CC3)NC2=CC=1Cl |
| MFCD | MFCD08703121 |
| InChi | InChI=1S/C13H15ClN4O/c1-17-4-6-18(7-5-17)13(19)12-15-10-3-2-9(14)8-11(10)16-12/h2-3,8H,4-7H2,1H3,(H,15,16) |
| InChiKey | MOIWSUQWIOVGRH-UHFFFAOYSA-N |
| CID | 10446295 |
| Short Description | H4 antagonist |
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