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Loratadine
- SCH 29851
- Soluble in EtOH
- MF: C22H23ClN2O2
- MW: 382.88
Description
Loratadine is a selective histamine H1 receptor antagonist/inverse agonist with a non-sedating antihistamine profile.
H1 receptor signaling mediates allergic inflammation, vascular permeability, pruritus and smooth muscle responses. Loratadine is used as a reference H1 antagonist for studying histamine-driven inflammatory and allergic mechanisms.
Key Features
- Selective H1 receptor antagonist/inverse agonist
- Non-sedating antihistamine pharmacology
- Blocks histamine-mediated allergic responses
- Useful reference compound for H1 receptor studies
Applications
- H1 receptor binding and functional assays
- Allergic inflammation research
- Mast cell and histamine response studies
- Antihistamine comparator profiling
More Information
| Parent CAS No. | 79794-75-5 |
|---|---|
| Chemical Name | 4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidine-1-carboxylic acid ethyl ester |
| SMILES | C1(=C2/C3N=CC=CC=3CCC3C=C(Cl)C=CC/2=3)CCN(C(=O)OCC)CC1 |
| MFCD | MFCD00672869 |
| InChi | InChI=1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3 |
| InChiKey | JCCNYMKQOSZNPW-UHFFFAOYSA-N |
| CID | 3957 |
| Short Description | H1 antagonist |
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