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Iodophenpropit dihydrobromide
- VUF 4586
- Parent CAS: 145196-88-9
- Soluble in DMSO and EtOH
- MF: C15H19IN4S.2HBr
- MW: 576.13
Description
Iodophenpropit dihydrobromide is a potent and selective histamine H3 receptor antagonist.
H3 antagonists block presynaptic feedback inhibition and are useful for increasing histaminergic neurotransmission in experimental systems. Iodophenpropit is also valuable in receptor binding and ligand-displacement studies involving H3 receptor pharmacology.
Key Features
- Potent selective H3 receptor antagonist
- Blocks presynaptic H3 receptor feedback
- Useful for H3 binding and displacement studies
- Relevant to CNS histaminergic neurotransmission research
Applications
- H3 receptor binding assays
- Histamine release and neurotransmission studies
- CNS receptor antagonist profiling
- Histamine receptor subtype selectivity research
More Information
| Parent CAS No. | 145196-88-9 |
|---|---|
| Chemical Name | 2-[3-(1H-Imidazol-4-yl)-propyl]-1-[2-(4-iodo-phenyl)-ethyl]-isothiourea dihydrobromide |
| SMILES | C1(=CNC=N1)CCCSC(=N)NCCC1C=CC(I)=CC=1.Br.Br |
| MFCD | MFCD09753370 |
| InChi | InChI=1S/C15H19IN4S.2BrH/c16-13-5-3-12(4-6-13)7-8-19-15(17)21-9-1-2-14-10-18-11-20-14;;/h3-6,10-11H,1-2,7-9H2,(H2,17,19)(H,18,20);2*1H |
| InChiKey | BOSOGNBLIWPCMS-UHFFFAOYSA-N |
| CID | 24978528 |
| Short Description | H3 antagonist |
References
- Leurs et al. Evaluation of the receptor selectivity of the H3 receptor antagonists, iodophenpropit and thioperamide: an interaction with the 5-HT3 receptor revealed. Br. J. Pharmacol. 1995, 116(4), 2315–2321.
- Jansen et al. Characterisation of the binding of the first selective radiolabelled histamine H3 receptor antagonist, [125I]-iodophenpropit, to rat brain. r. J. Pharmacol. 1994, 113, 355.
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