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A 943931
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C17H21N5
- MW: 295.38
Description
More Information
| Parent CAS No. | 1027330-97-7 |
|---|---|
| Chemical Name | 4-[(3R)-3-aminopyrrolidin-1-yl]-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidin-2-amine |
| SMILES | C1(N)=NC(N2CC[C@@H](N)C2)=C2CCCC3=CC=CC=C3C2=N1 |&1:7,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C17H21N5/c18-12-8-9-22(10-12)16-14-7-3-5-11-4-1-2-6-13(11)15(14)20-17(19)21-16/h1-2,4,6,12H,3,5,7-10,18H2,(H2,19,20,21)/t12-/m1/s1 |
| InChiKey | SDTRYHWIXVHTLM-GFCCVEGCSA-N |
| CID | 25068753 |
| Short Description | H4 antagonist |
References
- MD Cowart et al. Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation models. J. Med. Chem. 2008, 51, 6547.
- R Leurs et al. Molecular and biochemical pharmacology of the histamine H4 receptor. Br. J. Pharmacol. 2009, 157, 14.
- RA Smits et al. Major advances in the development of histamine H4 receptor ligands. Drug Disc. Today. 2009, 14(15-16), 745.
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