Bulk Inquiry
Cyproheptadine hydrochloride
- Parent CAS: 129-03-3
- Soluble in DMSO and EtOH
- MF: C21H21N.HCl
- MW: 323.86
Description
Cyproheptadine hydrochloride is an antagonist of the histamine receptor (H1) and serotonin receptor (5-HT2A), and has been clinically used as an antiallergy drug. Moreover, cyproheptadine hydrochloride inhibits the enzymatic activity of Set7/9 with an IC50 value of 1.0 μM. Antipruritic drug.
More Information
| Parent CAS No. | 129-03-3 |
|---|---|
| Chemical Name | 1-Methyl-4-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenylidene)piperidine hydrochloride |
| SMILES | C1C2C=CC=CC=2/C(=C2CCN(C)CC2)/C2C=CC=CC=2C=1.Cl |
| MFCD | MFCD00012538 |
| InChi | InChI=1S/C21H21N.ClH/c1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21;/h2-11H,12-15H2,1H3;1H |
| InChiKey | ZPMVNZLARAEGHB-UHFFFAOYSA-N |
| CID | 13770 |
| Short Description | 5-HT2A/H1 antagonist |
References
- EL Engelhardt et al. Structure-activity relationships in the cyproheptadine series. J Med Chem. 1965 Nov;8(6):829-35.
- Y Takemoto et al. Identification of Cyproheptadine as an Inhibitor of SET Domain Containing Lysine Methyltransferase 7/9 (Set7/9) That Regulates Estrogen-Dependent Transcription. J Med Chem. 2016 Apr 28;59(8):3650-60.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1102 | Nefazodone hydrochloride |
From $93.50 |
| 1103 | MDL 100151 |
From $121.00 |
| 1104 | MDL 100907 |
From $121.00 |
| 1105 | MDL 100009 |
From $137.50 |
| 1106 | (±)-MDL 105725 |
From $176.00 |
| 1107 | (+)-MDL 105725 |
From $143.00 |
| 1108 | (-)-MDL 105725 |
From Inquiry |
| 1138 | Mirtazapine |
From $71.50 |
| 1143 | Aripiprazole |
From $82.50 |
| 1144 | Thio-aripiprazole |
From $154.00 |
| 1146 | Clozapine |
From $55.00 |
| 1147 | Isoclozapine |
From $148.50 |
| 1148 | GMC 1-169 |
From $165.00 |
| 1149 | GMC 61-39 |
From Inquiry |
| 1150 | GMC 2-83 |
From $176.00 |
| 1152 | GMC 1-165 |
From $154.00 |
| 1247 | PNU 22394 hydrochloride |
From $99.00 |
| 1299 | Loratadine |
From $77.00 |
| 1354 | Quetiapine fumarate |
From $82.50 |
| 1439 | Eplivanserin |
From $88.00 |
| 1445 | Dimebon |
From $66.00 |
| 1446 | Ziprasidone hydrochloride |
From $55.00 |
| 1450 | Ketanserin |
From $60.50 |
| 1453 | Fexofenadine hydrochloride |
From $60.50 |
