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(±)-MDL 105725
- Soluble in DMSO
- MF: C21H26FNO3
- MW: 359.43
Description
(±)-MDL 105725 is the racemic active metabolite of MDL 100907 (Axon 1104). The (+)- and (-)-enantiomers are available separately, enabling stereoselective analysis of the MDL 100907 metabolite series.
Metabolite standards are useful for studying pharmacokinetics, biotransformation and activity relationships of receptor ligands. (±)-MDL 105725 supports research into 5-HT2A antagonist metabolism and radioligand precursor chemistry.
Key Features
- Active metabolite of MDL 100907
- Racemic MDL 105725
- Enantiomers available for comparison
- Relevant to 5-HT2A antagonist metabolite studies
Applications
- Metabolite profiling
- 5-HT2A antagonist research
- Enantiomeric activity studies
- Radioligand precursor and reference standard workflows
More Information
| Parent CAS No. | 1018473-89-6 |
|---|---|
| Chemical Name | 3-({1-[2-(4-Fluoro-phenyl)-ethyl]-piperidin-4-yl}-hydroxy-methyl)-2-methoxy-phenol |
| SMILES | C1(=CC=CC(O)=C1OC)C(O)C1CCN(CCC2C=CC(F)=CC=2)CC1 |
| MFCD | MFCD10565917 |
| InChi | InChI=1S/C21H26FNO3/c1-26-21-18(3-2-4-19(21)24)20(25)16-10-13-23(14-11-16)12-9-15-5-7-17(22)8-6-15/h2-8,16,20,24-25H,9-14H2,1H3 |
| InChiKey | DVDGOKMQDYFKFY-UHFFFAOYSA-N |
| CID | 22733848 |
| Short Description | 5-HT2A antagonist |
References
- T Ullrich and KC Rice. A practical synthesis of the serotonin 5-HT2a receptor antagonist mdl 100907, its enantiomer and their 3-phenolic derivatives as precursors for [11c]labeled pet ligands. Bioorg. Med. Chem. 2000, 8(10), 2427-2432.
- J H Kehne et al. Effects of the Selective 5-HT2A Receptor Antagonist MDL 100,907 on MDMA-Induced Locomotor Stimulation in Rats.Neuropsychopharmacol. 1996, 15, 116-124.
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