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SB 242084 hydrochloride
- Parent CAS: 181632-25-7
- Soluble in DMSO
- MF: C21H19ClN4O2.HCl
- MW: 431.32
Description
SB 242084 hydrochloride is a selective and brain-penetrant serotonin 5-HT2C receptor antagonist.
5-HT2C receptors regulate mood, appetite, anxiety-related behavior and dopaminergic tone in CNS circuits. SB 242084 is useful for studying 5-HT2C-dependent neurotransmission and behavioral pharmacology.
Key Features
- Selective antagonist of 5-HT2C receptors
- Brain-penetrant CNS pharmacology
- Useful for dissecting serotonin receptor subtype function
- Modulates 5-HT2C-dependent neural signaling
Applications
- 5-HT2C receptor pharmacology
- CNS neurotransmission studies
- Behavioral and neuropsychiatric models
- GPCR antagonist selectivity assays
Note: The freebase SB 242084 is available as Axon 4092.
More Information
| Parent CAS No. | 181632-25-7 |
|---|---|
| Chemical Name | 6-chloro-5-methyl-N-(6-(2-methylpyridin-3-yloxy)pyridin-3-yl)indoline-1-carboxamide hydrochloride |
| SMILES | N1(C2C=C(Cl)C(C)=CC=2CC1)C(NC1C=NC(OC2C(C)=NC=CC=2)=CC=1)=O.Cl |
| MFCD | MFCD02684417 |
| InChi | InChI=1S/C21H19ClN4O2.ClH/c1-13-10-15-7-9-26(18(15)11-17(13)22)21(27)25-16-5-6-20(24-12-16)28-19-4-3-8-23-14(19)2;/h3-6,8,10-12H,7,9H2,1-2H3,(H,25,27);1H |
| InChiKey | WOKOGXKQXNESDA-UHFFFAOYSA-N |
| CID | 72201049 |
| Short Description | 5-HT2C antagonist |
References
- SM Bromidge et al. 6-Chloro-5-methyl-1-[[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]-indoline (SB-242084): the first selective and brain penetrant 5-HT2C receptor antagonist. J. Med. Chem. 1997, 40(22), 3494-3496.
- GA Kennet et al. SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist. Neuropharmacology 1997, 36(4-5), 609-620.
- GL Dalton et al. Serotonin 1B and 2C receptor interactions in the modulation of feeding behaviour in the mouse. Psychopharmacol. 2006, 185(1), 45-57.
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