Bulk Inquiry
Sertindole
- LU 23-174
- Soluble in DMSO
- MF: C24H26ClFN4O
- MW: 440.94
Description
Sertindole is an atypical antipsychotic research compound with 5-HT2, dopamine D2 and α1-adrenoceptor antagonist activity. It has been described as showing prominent selectivity for brain limbic areas and long-lasting effects.
Sertindole's multi-receptor profile is relevant to antipsychotic mechanism studies, especially interactions between serotonergic, dopaminergic and adrenergic signaling. It is useful for comparative profiling of atypical antipsychotic receptor pharmacology.
Key Features
- 5-HT2 receptor antagonist activity
- Dopamine D2 receptor antagonist activity
- α1-adrenoceptor antagonist activity
- Atypical antipsychotic reference compound
Applications
- Antipsychotic mechanism research
- Serotonin-dopamine receptor profiling
- Limbic pathway pharmacology
- Multi-target CNS drug comparison
More Information
| Parent CAS No. | 106516-24-9 |
|---|---|
| Chemical Name | 1-(2-{4-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one |
| SMILES | C1N(C2C=CC(F)=CC=2)C2C=CC(Cl)=CC=2C=1C1CCN(CCN2CCNC2=O)CC1 |
| MFCD | MFCD00867749 |
| InChi | InChI=1S/C24H26ClFN4O/c25-18-1-6-23-21(15-18)22(16-30(23)20-4-2-19(26)3-5-20)17-7-10-28(11-8-17)13-14-29-12-9-27-24(29)31/h1-6,15-17H,7-14H2,(H,27,31) |
| InChiKey | GZKLJWGUPQBVJQ-UHFFFAOYSA-N |
| CID | 60149 |
| Short Description | Antipsychotic |
References
- A Hale, JM Azorin, S Kasper et al. Sertindole is associated with a low level of extrapyramidal symptoms in schizophrenic patients: Results of a phase III trial. Int. J. Psychiatry Clin. Pract. 2000, 4, 47-54.
- S Miyamoto et al. Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs. Mol. Psychiatry2005, 10, 79-104.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1086 | WAY 100635 hydrochloride |
From $137.50 |
| 1087 | Desmethyl-WAY 100635 trihydrochloride |
From $159.50 |
| 1102 | Nefazodone hydrochloride |
From $93.50 |
| 1103 | MDL 100151 |
From $121.00 |
| 1104 | MDL 100907 |
From $121.00 |
| 1105 | MDL 100009 |
From $137.50 |
| 1106 | (±)-MDL 105725 |
From $176.00 |
| 1107 | (+)-MDL 105725 |
From $143.00 |
| 1108 | (-)-MDL 105725 |
From Inquiry |
| 1118 | RO 60-0175 |
From $154.00 |
| 1143 | Aripiprazole |
From $82.50 |
| 1144 | Thio-aripiprazole |
From $154.00 |
| 1146 | Clozapine |
From $55.00 |
| 1147 | Isoclozapine |
From $148.50 |
| 1148 | GMC 1-169 |
From $165.00 |
| 1149 | GMC 61-39 |
From Inquiry |
| 1150 | GMC 2-83 |
From $176.00 |
| 1151 | GMC 1-116 |
From $154.00 |
| 1152 | GMC 1-165 |
From $154.00 |
| 1214 | MK 212 hydrochloride |
From $82.50 |
| 1236 | SKF 83566 hydrobromide |
From $99.00 |
| 1247 | PNU 22394 hydrochloride |
From $99.00 |
| 1298 | Olanzapine |
From $82.50 |
| 1354 | Quetiapine fumarate |
From $82.50 |
