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MDL 100151
- (±)-MDL 100907
- Soluble in DMSO and EtOH
- MF: C22H28FNO3
- MW: 373.46
Description
MDL 100151 is a selective 5-HT2A receptor antagonist and the racemic form related to M 100907/MDL 100907 (Axon 1104). It is used as a reference standard in PET/SPECT studies involving [11C]MDL100907.
5-HT2A receptors are central to cortical serotonergic signaling, antipsychotic pharmacology and neuroimaging studies. MDL 100151 provides a racemic comparator for enantiomerically active MDL 100907 and related radioligand workflows.
Key Features
- Selective 5-HT2A receptor antagonist
- Racemic M 100907-related compound
- Reference standard for [11C]MDL100907 PET/SPECT studies
- Useful comparator for the active enantiomer MDL 100907
Applications
- 5-HT2A receptor pharmacology
- Serotonergic antagonist profiling
- PET/SPECT neuroimaging research
- Enantiomeric activity comparison
More Information
| Parent CAS No. | 139290-69-0 |
|---|---|
| Chemical Name | (2,3-Dimethoxy-phenyl)-{1-[2-(4-fluoro-phenyl)-ethyl]-piperidin-4-yl}-methanol |
| SMILES | C1(=CC=CC(OC)=C1OC)C(O)C1CCN(CCC2C=CC(F)=CC=2)CC1 |
| MFCD | MFCD08061426 |
| InChi | InChI=1S/C22H28FNO3/c1-26-20-5-3-4-19(22(20)27-2)21(25)17-11-14-24(15-12-17)13-10-16-6-8-18(23)9-7-16/h3-9,17,21,25H,10-15H2,1-2H3 |
| InChiKey | HXTGXYRHXAGCFP-UHFFFAOYSA-N |
| CID | 60858 |
| Short Description | 5-HT2A antagonist |
References
- HO Kalkman et al. Cataleptogenic effect of subtype selective 5-HT receptor antagonists in the rat. Eur. J. Pharmacol. 1998, 343(2-3), 201-7.
- J H Kehne et al. Effects of the Selective 5-HT2A Receptor Antagonist MDL 100,907 on MDMA-Induced Locomotor Stimulation in Rats.Neuropsychopharmacol. 1996, 15, 116-124.
- C Sanchez et al. In-vivo assessment of 5-HT2A and 5-HT2C antagonistic properties of newer antipsychotics. Behav. Pharmacol. 2000, 11, 291-98.
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