Bulk Inquiry
A 77-01
- Soluble in DMSO
- MF: C18H14N4
- MW: 286.33
Description
Potent inhibitor of TGF-β type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM. A-77-01 is a close analogue of A-83-01 (Axon 1421) and has a very similar biological profile of A-83-01. A-83-01 is found to decompose to A-77-01 under certain circumstances and A-77-01 is likely an active component or metabolite of its prodrug A-83-01.
More Information
| Parent CAS No. | 607737-87-1 |
|---|---|
| Chemical Name | 4-(3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)quinoline |
| SMILES | C1C=C2C(C3=CNN=C3C3N=C(C)C=CC=3)=CC=NC2=CC=1 |
| MFCD | MFCD07367791 |
| InChi | InChI=1S/C18H14N4/c1-12-5-4-8-17(21-12)18-15(11-20-22-18)13-9-10-19-16-7-3-2-6-14(13)16/h2-11H,1H3,(H,20,22) |
| InChiKey | KJTYZDORHCDZPS-UHFFFAOYSA-N |
| CID | 10469233 |
| Short Description | ALK5 inhibitor |
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