Rossignoli, G., Oberhuemer, M., Brun, I. S., Zorzan, I., Osnato, A., Wenzel, A., ... & Martello, G. (2025). Feeder-free culture of naive human pluripotent stem cells retaining embryonic, extraembryonic and blastoid generation potential. bioRxiv, 2025-01.

* PD0325901, XAV939, GO6983, Y27632, CHIR99021, A83-01, SB431542, PD173174, etc from Axon Medchem

 

Arboit, M., Zorzan, I., Pensabene, E., Pellegrini, M., Bertelli, F., Panebianco, G., ... & Martello, G. (2025). KLF7 is a general inducer of human pluripotency. EMBO reports, 26(22), 5372.

* PD0325901, CHIR99021, XAV939, GO6983, Y27632, CHIR99021, A83-01, SB432542, etc from Axon Medchem

 

Juksar, J., Mijdam, R., Bosman, S., Van Oudenaarden, A., Carlotti, F., & de Koning, E. J. (2025). Effects of Neurogenin 3 Induction on Endocrine Differentiation and Delamination in Adult Human Pancreatic Ductal Organoids. Transplant International, 38, 13422.

* CHIR99021 and A83-01 from Axon Medchem

 

Van Nerum, K., Wenzel, A., Argemi-Muntadas, L., Kafkia, E., Drews, A., Brun, I. S., ... & Żylicz, J. J. (2025). α-Ketoglutarate promotes trophectoderm induction and maturation from naive human embryonic stem cells. Nature Cell Biology, 27(5), 749-761.

* PD0325901, CHIR99021, GO6983, XAV939, Y27632 A83-01, Sb431542, VPA, etc from Axon Medchem

 

Horcas-Nieto, J. M., Kiyuna, L. A., Langelaar-Makkinje, M., Gerding, A., Bonanini, M. J. B. F., Singh, M., ... & Bakker, B. M. (2025). iPSC-derived liver organoids as a tool to study Medium Chain Acyl-CoA Dehydrogenase deficiency. The role of peroxisomes in malnutrition and metabolic, 167.

*Y27632, A83-01, WY14643 from Axon Medchem

 

Gatimel, N., Perez, G., Bruno, E., Sagnat, D., Rolland, C., Tanguy-Le-Gac, Y., ... & Vergnolle, N. (2025). Human fallopian tube organoids provide a favourable environment for sperm motility. Human Reproduction, 40(3), 503-517.

* Y27632 and A83-01 from Axon Medchem

 

Cesana, M., Tufano, G., Panariello, F., Zampelli, N., Soldati, C., Mutarelli, M., ... & Ballabio, A. (2024). TFEB controls syncytiotrophoblast formation and hormone production in placenta. Cell Death & Differentiation, 31(11), 1439-1451.

* 4i: CHIR99021, A83-01, SB431542, and Y27632 from Axon Medchem

 

Onfray, C., Chevolleau, S., Moinard, E., Girard, O., Mahadik, K., Allsop, R., ... & David, L. (2024). Unraveling hallmark suitability for staging pre-and post-implantation stem cell models. Cell Reports, 43(5).

* CHIR99021, PD0325901, Y27632, A83-01, SB431542, GO6983, XAV927, IWR-1-endo from Axon Medchem

 

Arboit, M., Zorzan, I., Pellegrini, M., Martini, P., Carbognin, E., & Martello, G. (2023). KLF7 is a general inducer of human pluripotency. bioRxiv, 2023-09.

*7i: PD0325901, Y27632, XAV939, GO6983, CHIR99021, A83-01, SB432541 from Axon Medchem

 

Oldak, B., Wildschutz, E., Bondarenko, V., Comar, M. Y., Zhao, C., Aguilera-Castrejon, A., ... & Hanna, J. H. (2023). Complete human day 14 post-implantation embryo models from naive ES cells. Nature, 622(7983), 562-573.

https://www.nature.com/articles/s41586-023-06604-5.

*7i from Axon Medchem, incl GO6983, PD0325901, CGP77675, Y27632, BIR796, A83-01, CHIR99021

 

Zorzan, I., Betto, R. M., Rossignoli, G., Arboit, M., Drusin, A., Corridori, C., ... & Martello, G. (2023). Chemical conversion of human conventional PSCs to TSCs following transient naive gene activation. EMBO reports, 24(4), e55235.

* PD0325901, XAV939, GO6983, Y27632, CHIR99021, A83-01 and SB431542 from Axon Medchem

 

Zorzan, I., Betto, R. M., Rossignoli, G., Arboit, M., Drusin, A., Martini, P., & Martello, G. (2022). Chemical conversion of human conventional Pluripotent Stem Cells to Trophoblast Stem Cells. bioRxiv, 2022-04.

*PD0325901, XAV939, Go6983, Y27632, CHIR99021, A83-01, SB431542 from Axon Medchem

 

Castel, G., & David, L. (2022). Induction of human trophoblast stem cells. Nature protocols, 17(12), 2760-2783.

* Y27632, CHIR99021, A83-01, SB431542, PD0325901, GO6983, IWR-endo-1, Foskolin from Axon Medchem

 

Viukov, S., Shani, T., Bayerl, J., Sheban, D., Stelzer, Y., Novershtern, N., & Hanna, J. H. (2022). Human primed and naïve PSCs are both competent in differentiating into bona fide trophoblast stem cells. BioRxiv, 2022-05.

* 7i: PD0325901, XAV939, Go6983, Y27632, CHIR99021, A83-01, CGP77675 from Axon Medchem

 

Bayerl, J., Ayyash, M., Shani, T., Manor, Y. S., Gafni, O., Massarwa, R., ... & Hanna, J. H. (2021). Principles of signaling pathway modulation for enhancing human naive pluripotency induction. Cell Stem Cell.

* CHIR99021 and 14i from Axon Medchem (including PD0325901, IWR1, BIR0796, Go6983, Y27632, CGP77675, RIN1, LDN193189, A83-01, SB590885, BIX02189, RU-SKI43, BIX01294.

 

Steinberg, D. J., Repudi, S., Saleem, A., Kustanovich, I., Viukov, S., Abudiab, B., ... & Aqeilan, R. I. (2021). Modeling genetic epileptic encephalopathies using brain organoids. EMBO molecular medicine, 13(8), e13610.

* CHIR99021, A83-01 and LDN 193189 from Axon Medchem

 

Coll, M., Ariño, S., Martínez-Sánchez, C., Garcia-Pras, E., Gallego, J., Moles, A., ... & Sancho-Bru, P. (2021). Ductular reaction promotes intrahepatic angiogenesis through Slit2-Roundabout 1 signaling. Hepatology (Baltimore, Md.).

* CHIR99021, Y 27632, A83-01 and Forskolin from Axon Medchem

 

Castel, G., Meistermann, D., Bretin, B., Firmin, J., Blin, J., Loubersac, S., ... & David, L. (2020). Induction of Human Trophoblast Stem Cells from Somatic Cells and Pluripotent Stem Cells. Cell Reports, 33(8), 108419.

* 8 inhibitors are from Axon Medchem, including CHIR99021, PD 0325901, Y 27632, IWR-1, A83-01, SB4 31542, Go 6983, Forskolin.

 

Bayerl, J., Ayyash, M., Shani, T., Manor, Y., Gafni, O., Kalma, Y., ... & Hanna, J. H. (2020). Tripartite Inhibition of SRC-WNT-PKC Signalling Consolidates Human Naïve Pluripotency. bioRxiv.

* CHIR99021, PD 0325901, IWR-1, XAV 939, BIRB0796, Go6983, Y27632, CGP77675, LDN193189, A83-01, DBZ, SB590885, BIX02189, RU-SKI43, BIX-02194

 

Steinberg, D. J., Saleem, A., Repudi, S. R., Banne, E., Mahajnah, M., Hanna, J. H., ... & Aqeilan, R. I. (2020). Modeling Genetic Epileptic Encephalopathies using Brain Organoids. bioRxiv.

* CHIR99021, LDN193189, A83-01 from Axon Medchem

 

Zorzan, I., Pellegrini, M., Arboit, M., Incarnato, D., Maldotti, M., Forcato, M., ... & Martello, G. (2020). The transcriptional regulator ZNF398 mediates pluripotency and epithelial character downstream of TGF-beta in human PSCs. Nature Communications, 11(1), 2364.

* Y27632, SB431542, LDN193189, A83-01 from Axon Medchem

 

Aguilar‐Bravo, B., Rodrigo‐Torres, D., Ariño, S., Coll, M., Pose, E., Blaya, D., ... & Dubuquoy, L. (2018). Ductular reaction cells display an inflammatory profile and recruit neutrophils in alcoholic hepatitis. Hepatology.

* CHIR99021, Y27632 and A83-01 from Axon Medchem