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SMURF1 inhibitor A01

Name: SMURF1 inhibitor A01
SKU: 2426

- A01

Axon 2426

CAS: 1007647-73-5

Purity: 99%

Soluble in DMSO

MF: C22H20ClF3N4O3S
MW: 512.93

Description

SMAD ubiquitination regulatory factor-1 (SMURF1) E3 ubiquitin-protein ligase inhibitor (Kd value 3.7 nM), that strongly inhibits Smad1/5 ubiquitination under rhBMP-2 stimulation. A01 enhances BMP signaling responsiveness in C2C12 cells, and potentiates BMP-2 induced osteoblastic activity.

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Certificate of Analysis (B1)

Material Safety Data Sheet (B1)

Ubiquitin Ligase (E3; SMURF)

Parent CAS No.	1007647-73-5
Chemical Name	(4-(4-chloro-3-(trifluoromethyl)phenylsulfonyl)piperazin-1-yl)(4-(5-methyl-1H-pyrazol-1-yl)phenyl)methanone
SMILES	C1(C(F)(F)F)C=C(S(=O)(=O)N2CCN(C(=O)C3C=CC(N4N=CC=C4C)=CC=3)CC2)C=CC=1Cl
MFCD	N.A.
InChi	InChI=1S/C22H20ClF3N4O3S/c1-15-8-9-27-30(15)17-4-2-16(3-5-17)21(31)28-10-12-29(13-11-28)34(32,33)18-6-7-20(23)19(14-18)22(24,25)26/h2-9,14H,10-13H2,1H3
InChiKey	QFYLTUDRXBNZFQ-UHFFFAOYSA-N
CID	17555704
Short Description	SMURF1 inhibitor

SMURF1 inhibitor A01 CAS 1007647-73-5 Axon 2426 SMURF1 inhibitor Axon Ligands Axon Medchem Supplier Axon2426 Ubiquitin Ligase (E3; SMURF) Smad BMP-2 CDK8 HECT A01 Vendor

References

Y. Cao et al. Selective small molecule compounds increase BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation. Sci Rep. 2014 May 14;4:4965. doi: 10.1038/srep04965.

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SMURF1 inhibitor A01

Description

More Information

References

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