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TCID
- Soluble in DMSO
- MF: C9H2Cl4O2
- MW: 283.92
Description
TCID is a potent, cell-permeant inhibitor of ubiquitin C-terminal hydrolase L3 (UCHL3) with an IC50 value of 0.6 μM and 125-fold selectivity over UCHL1. It reduces GlyT2 ubiquitination in brainstem and spinal cord primary neurons.
UCHL3 is a deubiquitinase that regulates protein ubiquitination dynamics in neuronal and cellular pathways. TCID is useful for studying UCHL3-dependent ubiquitin signaling, glycine transporter regulation and neurological disease-relevant mechanisms.
Key Features
- Cell-permeant UCHL3 inhibitor
- IC50: 0.6 μM
- 125-fold selectivity over UCHL1
- Modulates GlyT2 ubiquitination in primary neurons
Applications
- Deubiquitinase pharmacology
- UCHL3 selectivity studies
- GlyT2 and neuronal transporter research
- Pain, epilepsy and neuromotor disease models
More Information
| Parent CAS No. | 30675-13-9 |
|---|---|
| Chemical Name | 4,5,6,7-tetrachloro-1H-indene-1,3(2H)-dione |
| SMILES | C1(=O)C2=C(C(Cl)=C(Cl)C(Cl)=C2Cl)C(=O)C1 |
| MFCD | MFCD00239209 |
| InChi | InChI=1S/C9H2Cl4O2/c10-6-4-2(14)1-3(15)5(4)7(11)9(13)8(6)12/h1H2 |
| InChiKey | IDLAOWFFKWRNHB-UHFFFAOYSA-N |
| CID | 2729042 |
| Short Description | UCHL3 inhibitor |
References
- Y. Liu et al. Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem. Biol. 2003, 10, 837-846.
- J. de Juan-Sanz et al. Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 is dependent on ubiquitination of a C-terminal lysine cluster. PLoS One. 2013, 8, e58863.
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