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P 005091
- P 5091
- Soluble in DMSO
- MF: C12H7Cl2NO3S2
- MW: 348.22
Description
Selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) and the closely related USP47; inhibits USP7-mediated p53 deubiquitination; enhances the degradation of the USP7 substrate HDM2 in tumor cells; induces apoptosis in MM cells resistant to conventional and bortezomib (Axon 1810) therapies
More Information
| Parent CAS No. | 882257-11-6 |
|---|---|
| Chemical Name | 1-(5-(2,3-dichlorophenylthio)-4-nitrothiophen-2-yl)ethanone |
| SMILES | C1C(SC2SC(C(C)=O)=CC=2[N+]([O-])=O)=C(Cl)C(Cl)=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C12H7Cl2NO3S2/c1-6(16)10-5-8(15(17)18)12(20-10)19-9-4-2-3-7(13)11(9)14/h2-5H,1H3 |
| InChiKey | LKZLGMAAKNEGCH-UHFFFAOYSA-N |
| CID | 2819993 |
| Short Description | USP7 inhibitor |
References
- B Nicholson, KGS Kumar. The multifaceted roles of USP7: new therapeutic opportunities. Cell Biochem. Biophys. 2011, 60(1-2), 61-68.
- D Chauhan et al. A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance. Cancer Cell. 2012, 22(3), 345-358.
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