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ML364
- Soluble in DMSO
- MF: C24H18F3N3O3S2
- MW: 517.54
Description
ML364 is a potent, reversible inhibitor of the deubiquitinase USP2, with an IC50 of 1.1 µM. By inhibiting USP2-mediated deubiquitination, ML364 promotes ubiquitin-dependent degradation of cyclin D1 and induces cell-cycle arrest in cyclin D1-dependent cancer models.
ML364 impairs RAD51-mediated homologous recombination, blocking DNA repair and cell proliferation. ML364 serves as a useful chemical for studying USP2-regulated protein stability and G1/S progression.
Key Features
- Potent and reversible USP2 inhibitor with low IC50 of 1.1 µM
- Accelerates cyclin D1 degradation
- Reduces homologous recombination-mediated DNA repair
- Increases ROS, decreases ATP
Applications
- USP2 and deubiquitinase biology
- Cyclin D1 stability and cell-cycle control
- Homologous recombination and RAD51 studies
- Colorectal cancer and mantle cell lymphoma models
More Information
| Parent CAS No. | 1991986-30-1 |
|---|---|
| Chemical Name | 2-(4-Methylphenylsulfonamido)-N-(4-phenylthiazol-2-yl)-4-(trifluoromethyl)benzamide |
| SMILES | C1(C(NC2=NC(C3C=CC=CC=3)=CS2)=O)C(NS(=O)(=O)C2C=CC(C)=CC=2)=CC(C(F)(F)F)=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C24H18F3N3O3S2/c1-15-7-10-18(11-8-15)35(32,33)30-20-13-17(24(25,26)27)9-12-19(20)22(31)29-23-28-21(14-34-23)16-5-3-2-4-6-16/h2-14,30H,1H3,(H,28,29,31) |
| InChiKey | QZUGMNXETPARLI-UHFFFAOYSA-N |
| CID | 70789348 |
| Short Description | USP2 inhibitor |
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