Hydrolases

The group of hydrolases (EC 3.-.-.-) consists of 13 subgroups, as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology. Only few of them are represented in the Axon Ligands™ catalogue. The enzymes that catalyze the hydrolysis of various bonds are classified by the nature of the chemical bonds they cleave. Examples of enzymes of this group of enzymes are esterases, peptidases, and deacetylases.

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Axon ID Name Description From price
3144 (+)-Blebbistatin Negative control of (±)-Blebbistatin as an inhibitor of class II myosins €90.00
1730 (+)-Kifunensine α-mannosidase inhibitor €120.00
3074 (-)-Blebbistatin Selective inhibitor of class II myosins; Active enantiomer of (±)-Blebbistatin €90.00
1229 (R)-(-)-Rolipram PDE4 inhibitor €110.00
1432 (S)-(+)-Rolipram PDE4 inhibitor €115.00
2296 (S)-Crizotinib MTH1 inhibitor €85.00
2718 (±)-Blebbistatin Potent and specific inhibitor of class II myosins €95.00
2434 1-Deazaadenosine Adenosine deaminase (ADA) inhibitor with cytostatic activity in vitro €140.00
1666 A 357300 hydrochloride MetAP2 inhibitor €90.00
3718 AB-680 ammonium salt CD73 inhibitor Inquire
3729 ABBV-CLS-484 hydrochloride Inhibitor of phosphatase PTPN1/N2 (Protein Tyrosine Phosphatase Non-Receptor Type 1 and 2), Inquire
3000 ABX-1431 Highly potent, selective, brain-penetrant, and orally available MAGL inhibitor €135.00
3590 ACT001 PAI-1 inhibitor €210.00
3039 ACY-241 Selective and orally available HDAC6 inhibitor €120.00
2083 ADAMTS-5 inhibitor Selective inhibitor of ADAMTS-5 (aggrecanase-2) €140.00
1571 AG 7088 HRV3C protease inhibitor €60.00
2269 AK 1 Potent inhibitor of SIRT with good selectivity for SIRT2 over SIRT1 and SIRT3 €90.00
2270 AK 7 Potent, brain-permeable and selective inhibitor of SIRT2 €90.00
3310 Alogliptin benzoate Potent, highly selective and orally active DPP-4 inhibitor €65.00
3465 Amenamevir Potent helicase-primase inhibitor €130.00
3575 AMG510 Highly potent, selective, and orally bioavailable KRAS-G12C inhibitor €90.00
3682 AMZ30 Potent, selective and covalent PME-1 inhibitor  Recently added €130.00
2137 APE1 Inhibitor III Inhibitor of apurinic/apyrimidinic endonuclease 1 (APE1) €110.00
1754 Apixaban Factor Xa inhibitor €95.00
2006 Apoptosis Activator 2 A cell-permeable apoptosis activator €75.00
2251 Apoptozole Inhibitor of ATPase activity of Hsc70 and Hsp70 €95.00
1957 Apremilast PDE4 inhibitor €60.00
2394 AR-42 HDAC inhibitor €125.00
2136 AR03 Inhibitor of apurinic/apyrimidinic endonuclease 1 (APE1) €105.00
2307 ARM1 hydrobromide Novel type of LTA4H inhibitor that selectively blocks the conversion of LTA4 into LTB4 €92.00

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