Hydrolases
The group of hydrolases (EC 3.-.-.-) consists of 13 subgroups, as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology. Only few of them are represented in the Axon Ligands™ catalogue. The enzymes that catalyze the hydrolysis of various bonds are classified by the nature of the chemical bonds they cleave. Examples of enzymes of this group of enzymes are esterases, peptidases, and deacetylases.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 1666 | A 357300 hydrochloride | MetAP2 inhibitor | €95.00 | |
| 2083 | ADAMTS-5 inhibitor | Selective inhibitor of ADAMTS-5 (aggrecanase-2) | €135.00 | |
| 1571 | AG 7088 | HRV3C protease inhibitor | €135.00 | |
| 2269 | AK 1 | Potent inhibitor of SIRT with good selectivity for SIRT2 over SIRT1 and SIRT3 | €90.00 | |
| 2270 | AK 7 | Potent, brain-permeable and selective inhibitor of SIRT2 | €90.00 | |
| 1754 | Apixaban | Factor Xa inhibitor | €125.00 | |
| 2006 | Apoptosis Activator 2 | A cell-permeable apoptosis activator | €75.00 | |
| 2251 | Apoptozole | Inhibitor of ATPase activity of Hsc70 and Hsp70 | €95.00 | |
| 1957 | Apremilast | PDE4 inhibitor | €105.00 | |
| 2394 | AR-42 | HDAC inhibitor | Recently added | €125.00 |
| 2307 | ARM1 hydrobromide | Novel type of LTA4H inhibitor that selectively blocks the conversion of LTA4 into LTB4 | €92.00 | |
| 2578 | ASB14780 | Potent, orally available inhibitor of cPLA2α; antiinflammatory drug | €120.00 | |
| 2276 | Atglistatin | Potent and selective inhibitor of adipose triglyceride lipase (ATGL) | €90.00 | |
| 2661 | AZD2716 | Potent secreted phospholipase A2 (sPLA2) inhibitor | €145.00 | |
| 1125 | BACE-1 Inhibitor | BACE 1 inhibitor | €110.00 | |