Hydrolases
The group of hydrolases (EC 3.-.-.-) consists of 13 subgroups, as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology. Only few of them are represented in the Axon Ligands™ catalogue. The enzymes that catalyze the hydrolysis of various bonds are classified by the nature of the chemical bonds they cleave. Examples of enzymes of this group of enzymes are esterases, peptidases, and deacetylases.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 3144 | (+)-Blebbistatin | Negative control of (±)-Blebbistatin as an inhibitor of class II myosins | €90.00 | |
| 1730 | (+)-Kifunensine | α-mannosidase inhibitor | €120.00 | |
| 3074 | (-)-Blebbistatin | Selective inhibitor of class II myosins; Active enantiomer of (±)-Blebbistatin | €90.00 | |
| 1229 | (R)-(-)-Rolipram | PDE4 inhibitor | €110.00 | |
| 1432 | (S)-(+)-Rolipram | PDE4 inhibitor | €115.00 | |
| 2296 | (S)-Crizotinib | MTH1 inhibitor | €85.00 | |
| 2718 | (±)-Blebbistatin | Potent and specific inhibitor of class II myosins | €95.00 | |
| 2434 | 1-Deazaadenosine | Adenosine deaminase (ADA) inhibitor with cytostatic activity in vitro | €140.00 | |
| 4282 | 2-APQC | SIRT3 activator | Recently added | €160.00 |
| 1666 | A 357300 hydrochloride | MetAP2 inhibitor | €90.00 | |
| 3718 | AB-680 ammonium salt | CD73 inhibitor | Inquire | |
| 3729 | ABBV-CLS-484 hydrochloride | Inhibitor of phosphatase PTPN1/N2 (Protein Tyrosine Phosphatase Non-Receptor Type 1 and 2), | Inquire | |
| 3000 | ABX-1431 | Highly potent, selective, brain-penetrant, and orally available MAGL inhibitor | €135.00 | |
| 3590 | ACT001 | PAI-1 inhibitor | €210.00 | |
| 3039 | ACY-241 | Selective and orally available HDAC6 inhibitor | €120.00 | |
| 2083 | ADAMTS-5 inhibitor | Selective inhibitor of ADAMTS-5 (aggrecanase-2) | €140.00 | |
| 4000 | Aficamten | Next-in-class cardiac myosin inhibitor | €160.00 | |
| 3856 | AHU-377 tris salt | Inhibitor of Neprilysin | Inquire | |
| 2269 | AK 1 | Potent inhibitor of SIRT with good selectivity for SIRT2 over SIRT1 and SIRT3 | €90.00 | |
| 2270 | AK 7 | Potent, brain-permeable and selective inhibitor of SIRT2 | €90.00 | |
| 3310 | Alogliptin benzoate | Potent, highly selective and orally active DPP-4 inhibitor | €65.00 | |
| 3465 | Amenamevir | Potent helicase-primase inhibitor | €120.00 | |
| 3575 | AMG510 | Highly potent, selective, and orally bioavailable KRAS-G12C inhibitor | €90.00 | |
| 3682 | AMZ30 | Potent, selective and covalent PME-1 inhibitor | €130.00 | |
| 2137 | APE1 Inhibitor III | Inhibitor of apurinic/apyrimidinic endonuclease 1 (APE1) | €110.00 | |
| 1754 | Apixaban | Factor Xa inhibitor | €95.00 | |
| 2006 | Apoptosis Activator 2 | A cell-permeable apoptosis activator | €75.00 | |
| 2251 | Apoptozole | Inhibitor of ATPase activity of Hsc70 and Hsp70 | €95.00 | |
| 1957 | Apremilast | PDE4 inhibitor | €60.00 | |
| 2394 | AR-42 | HDAC inhibitor | €125.00 | |