ADAMTS-5

A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5; EC 3.2.24.xx) plays a role in  cartilage degradation, arthritis, procollagen processing, degradation of proteoglycans, and cancer, among others. It is a member of the metzincins superfamily of zinc-based proteinases[1], and 1 of the 19 members of a family of secreted metalloproteinases in humans. ADAMTS-5, also termed ADAMTS-11, aggrecanase-2 or implantin, falls under the subfamily of proteoglycanases within the ADAMTS family. All of the members of ADAMTS family have a similar structural organization with an N-terminal metalloproteinase domain followed by various ancillary domains at the C-terminal region[2]. Several members of the ADAMTS family possess some degree of aggrecanolytic activity in vitro, including ADAMTS-5. It cleaves human aggrecan to produce the fragments found in synovial fluid and cartilage[3].

MMP subclasses listed: ADAMTS-5, TACE


[1] T. Shiomi et al. Matrix metalloproteinases, a disintegrin and metalloproteinases, and a disintegrin and metalloproteinases with thrombospondin motifs in non-neoplastic diseases. Pathol. Int. 2010, 60, 477-496.
[2] S. Kumar et al. ADAMTS5 functions as an anti-angiogenic and anti-tumorigenic protein independent of its proteoglycanase activity. Am. J. Pathol. 2012, 181, 1056-1068.
[3] R.H. Song et al. Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5. Arthritis Rheum. 2007, 56, 575-585.

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Axon ID Name Description From price
2083 ADAMTS-5 inhibitor Selective inhibitor of ADAMTS-5 (aggrecanase-2) €135.00

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