TACE

TNF-α converting enzyme (TACE or ADAM17; EC 3.4.24.86), a pro-inflammatory cytokine, catalyzes the formation of TNF-α from membrane bound TNF-α precursor protein. It is is believed to play pathophysiological roles in inflammation, anorexia, cachexia, septic shock, viral replication and so on. What’s more, TNF-α is a key player in inflammation and joint damage in rheumatoid arthritis. To control the level of TNF-α release, inhibition of TACE activity has long been considered as a promising way of treating related inflammatory diseases for which one of the most attractive strategies is the development of low molecular mass inhibitors of TACE[1].

MMP subclasses listed: MMP (PCP), MMP-2MMP-3MMP-9MMP-12MMP-13MMP-14, ADAMTS-5, TACE


[1] P.R. Murumkar et al. Novel TACE inhibitors in drug discovery: a review of patented compounds. Expert Opin. Ther. Pat. 2010, 20, 31-57.

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Axon ID Name Description From price
1507 TMI 005 TACE/MMP inhibitor €125.00

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