MMP

Matrix metalloproteinases (MMPs; EC 3.4.24.-), also called matrixins, function in the extracellular environment of cells and degrade both matrix and non-matrix proteins. They play central roles in morphogenesis, wound healing, tissue repair and remodeling in response to injury, e.g. after myocardial infarction, and in progression of diseases such as atheroma, arthritis, cancer and chronic tissue ulcers. The activities of most matrixins are very low or negligible in the normal steady-state tissues, but expression is transcriptionally controlled by inflammatory cytokines, growth factors, hormones, cell–cell and cell–matrix interaction. MMPs are classified as the matrixin subfamily of zinc metalloprotease family (M10)[1].


[1] H. Nagase, R. Visse, G. Murphy. Structure and function of matrix metalloproteinases and TIMPs. Cardiovasc. Res. 2006, 69, 562-573.

8 Item(s)

per page
Axon ID Name Description From price
2104 CP 471474 MMP inhibitor €105.00
2162 NSC 405020 MT1-MMP inhibitor specifically targeting PEX-domain. €85.00
1271 PD 166793 MMP inhibitor €90.00
1181 PF 00356231 MMP-12 inhibitor €135.00
2328 PTIQ Neuroprotectant with attenuating effects on MMP-3 expression €125.00
2370 SB-3CT Potent and selective inhibitor of Gelatinases MMP-2 and MMP-9 €125.00
2111 UK 356618 Potent MMP-3 (aka Stromelysin-1) inhibitor €90.00
2073 UK 383367 Inhibitor of bone morphogenetic protein 1 (BMP-1, aka PCP) €80.00

8 Item(s)

per page
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