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PTIQ
Axon 2328
CAS:
1032822-42-6
Purity:
99%
- Soluble in 0.1N NaOH(aq), DMSO and EtOH
- MF: C13H17NO3
- MW: 235.28
Description
Brain penetrating neuroprotectant that attenuates MPTP induced motor deficits, prevents neurodegeneration and suppresses microglial activation in the substantia nigra. Mechanistically, PTIQ effectively suppresses expression of MMP-3 (IC50 value 60 nM in stressed dopaminergic cells), and NO production (IC50 value <100 µM in LPS stimulated BV-2 cells). PTIQ also inhibits IL-1β, TNF-α (IC50 value 6.5 µM) and COX-2 (IC50 value 9.3 µM) and blocked nuclear translocation of NF-κB, yet it shows no inhibition of hERG channels or CYP isozyme activities.
More Information
| Parent CAS No. | 1032822-42-6 |
|---|---|
| Chemical Name | 1-(7-hydroxy-6-methoxy-3,4-dihydroisoquinolin-2(1H)-yl)propan-1-one |
| SMILES | C(N1CCC2=C(C1)C=C(O)C(OC)=C2)(=O)CC |
| MFCD | N.A. |
| InChi | InChI=1S/C13H17NO3/c1-3-13(16)14-5-4-9-7-12(17-2)11(15)6-10(9)8-14/h6-7,15H,3-5,8H2,1-2H3 |
| InChiKey | BEDYMEDICHGLSE-UHFFFAOYSA-N |
| CID | 24812799 |
| Short Description | MMP3 expression modulator | Neuroprotectant |
References
- H.J. Son et al. A novel compound PTIQ protects the nigral dopaminergic neurones in an animal model of Parkinson's disease induced by MPTP. Br J Pharmacol. 2012 Apr;165(7):2213-27.
- J.W. Seo et al. Syntheses of tetrahydroisoquinoline derivatives that inhibit NO production in activated BV-2 microglial cells. Eur J Med Chem. 2008 Jun;43(6):1160-70.
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