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JSH 23
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C16H20N2
- MW: 240.34
Description
Inhibitor of NF-κB transcription and nuclear translocation of p65 (IC50 value 7.1 µM for inhibition of LPS-induced NF-κB transcriptional activity) without affecting IκBα degradation, which is a very rare mode of action. JSH 23 inhibited not only LPS-induced expressions of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6 and inducible nitric oxide synthase and cyclooxygenase-2 but also LPS-induced apoptosis of the RAW 264.7 cells.
JSF 23 also inhibits NO production in LPS-stimulated macrophages RAW 264.7 (IC50 value 14.4 µM).
More Information
| Parent CAS No. | 749886-87-1 |
|---|---|
| Chemical Name | 4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine |
| SMILES | C1(NCCCC2=CC=CC=C2)=CC=C(C)C=C1N |
| MFCD | MFCD09753595 |
| InChi | InChI=1S/C16H20N2/c1-13-9-10-16(15(17)12-13)18-11-5-8-14-6-3-2-4-7-14/h2-4,6-7,9-10,12,18H,5,8,11,17H2,1H3 |
| InChiKey | YMFNPBSZFWXMAD-UHFFFAOYSA-N |
| CID | 16760588 |
| Short Description | NF-κB inhibitor |
References
- K.R. Min et al. Anti-inflammatory effects of N1-benzyl-4-methylbenzene-1,2-diamine (JSH-21) analogs on nitric oxide production and nuclear factor-kappa B transcriptional activity.... Arch. Pharm. Res. 2004, 27, 1053-1059.
- H.Y. Fang et al. Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia. Blood. 2009, 114, 844-859.
- H.M. Shin et al. Inhibitory action of novel aromatic diamine compound on lipopolysaccharide-induced nuclear translocation of NF-kappaB without affecting IkappaB degradation. FEBS Lett. 2004, 571, 50-54.
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