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Parthenolide
- PTL
Axon 3614
CAS:
20554-84-1
- Optical Purity: Optically pure
- Soluble in DMSO and EtOH
- MF: C15H20O3
- MW: 248.32
Description
Parthenolide, a sesquiterpene lactone, is a potent inhibitor of nuclear factor-kappa B (NF-κB) activation and can inhibit the expression of pro-inflammatory cytokines in cultured cells and experimental animal models. Acting as a covalently reactive compound, Parthenolide displays anti-inflammatory, redox-modulating, and epigenetic activities, as well as selective cytotoxicity towards cancer stem and progenitor cells.
More Information
| Parent CAS No. | 20554-84-1 |
|---|---|
| Chemical Name | (1S,2R,4R,7E,11S)-4,8-Dimethyl-12-methylidene-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7-en-13-one |
| SMILES | C1C=C(C)CC[C@@]2([H])C(=C)C(=O)O[C@@H]2[C@H]2O[C@]2(C)C1 |c:1,&1:6,13,14,16,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5+/t11-,12-,13+,15+/m0/s1 |
| InChiKey | KTEXNACQROZXEV-PVLRGYAZSA-N |
| CID | 7251185 |
| Short Description | NF-κB inhibitor |
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