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ACT001
- Dimethylaminomicheliolide - DMAMCL
Axon 3590
CAS:
1403357-81-2
- Optical Purity: Optically pure
- Soluble in 0.1N HCl(aq), DMSO and EtOH
- MF: C17H27NO3
- MW: 293.4
Description
Dimethylaminomicheliolide (DMAMCL) is a PAI-1 inhibitor. The inhibition of PAI-1 induces glioma inhibition, and DMAMCL has a synergistic effect with cisplatin through the inhibition of the PAI-1/PI3K/AKT pathway. Also, DMAMCL exerts antitumor effects on neuroblastoma (NB) both in vitro and in vivo by suppressing aerobic glycolysis. PFKL could be a potential target of DMAMCL in NB. Its active parent drug Micheliolide (or MCL) is available as Axon 3607.
More Information
| Parent CAS No. | 1403357-81-2 |
|---|---|
| Chemical Name | (3R,3aS,9R,9aS,9bS,Z)-3-((Dimethylamino)methyl)-9-hydroxy-6,9-dimethyl-3,3a,4,5,7,8,9,9a-octahydroazuleno[4,5-b]furan-2(9bH)-one |
| SMILES | [C@@]12([H])[C@H]3OC(=O)[C@@H](CN(C)C)[C@@H]3CCC(C)=C1CC[C@]2(O)C |&1:0,2,6,11,19,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C17H27NO3/c1-10-5-6-12-13(9-18(3)4)16(19)21-15(12)14-11(10)7-8-17(14,2)20/h12-15,20H,5-9H2,1-4H3/t12-,13-,14-,15-,17+/m0/s1 |
| InChiKey | ZPBIJIIQXPRJSS-WNZSCWOMSA-N |
| CID | 52939461 |
| Short Description | PAI-1 inhibitor |
References
- S Zhang et al. Antitumor effects of the small molecule DMAMCL in neuroblastoma via suppressing aerobic glycolysis and targeting PFKL. Cancer Cell Int. 2021 Nov 24;21(1):619.
- X Xi et al. ACT001, a novel PAI-1 inhibitor, exerts synergistic effects in combination with cisplatin by inhibiting PI3K/AKT pathway in glioma. Cell Death Dis. 2019 Oct 7;10(10):757.
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