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TM 5441
Axon 2734
CAS:
1190221-43-2
Purity:
98%
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C21H17ClN2O6
- MW: 428.82
Description
TM5441 is an orally active PAI-1 inhibitor, which protects mice against L-NAME–induced vascular pathologies, including hypertension, fibrosis, and vascular senescence. TM5441 is a derivative of PAI-1 inhibitor TM5275 (Axon 2344), however showed better pharmacokinetics and volume of distribution.
More Information
| Parent CAS No. | 1190221-43-2 |
|---|---|
| Chemical Name | 5-Chloro-2-(2-(2-(3-(furan-3-yl)phenylamino)-2-oxoethoxy)acetamido)benzoic acid |
| SMILES | C1C=CC(NC(=O)COCC(=O)NC2C(C(=O)O)=CC(Cl)=CC=2)=CC=1C1=COC=C1 |
| MFCD | MFCD31382187 |
| InChi | InChI=1S/C21H17ClN2O6/c22-15-4-5-18(17(9-15)21(27)28)24-20(26)12-30-11-19(25)23-16-3-1-2-13(8-16)14-6-7-29-10-14/h1-10H,11-12H2,(H,23,25)(H,24,26)(H,27,28) |
| InChiKey | BGGMLMAPVODXAU-UHFFFAOYSA-N |
| CID | 44250349 |
| Short Description | PAI-1 inhibitor |
References
- AE Boe et al. Plasminogen activator inhibitor-1 antagonist TM5441 attenuates NĻ-nitro-L-arginine methyl ester-induced hypertension and vascular senescence. Circulation. 2013 Nov 19;128(21):2318-24.
- VR Placencio et al. Small Molecule Inhibitors of Plasminogen Activator Inhibitor-1 Elicit Anti-Tumorigenic and Anti-Angiogenic Activity. PLoS One. 2015 Jul 24;10(7):e0133786.
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