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PAZ-417

 - Aleplasinin
Axon 3710
CAS:  481629-87-2
Purity:  99%
  • Soluble in DMSO and EtOH
  • MF:  C28H27NO3
  • MW:  425.52

Description

PAZ-417 is a potent, orally active and CNS-penetrant inhibitor of PAI-1 (IC50 value of 655 nM) that promotes plasmin formation and proteolysis of Aβ. In transgenic mouse models of Alzheimer’s disease, PAZ-417 reduces Aβ levels in both plasma and brain and reverses both LTP and cognitive deficits.

More Information

Parent CAS No. 481629-87-2
Chemical Name 2-(1-(4-tert-Butylbenzyl)-5-m-tolyl-1H-indol-3-yl)-2-oxoacetic acid
SMILES C1(C2C=C(C)C=CC=2)C=C2C(C(C(=O)O)=O)=CN(CC3C=CC(C(C)(C)C)=CC=3)C2=CC=1
MFCD N.A.
InChi InChI=1S/C28H27NO3/c1-18-6-5-7-20(14-18)21-10-13-25-23(15-21)24(26(30)27(31)32)17-29(25)16-19-8-11-22(12-9-19)28(2,3)4/h5-15,17H,16H2,1-4H3,(H,31,32)
InChiKey HSXLMAFNWCSZGP-UHFFFAOYSA-N
CID 10224267
Short Description PAI-1 inhibitor

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