Plasminogen activator inhibitor-1 (PAI-1)
Plasminogen activator inhibitor (PAI-1; EC 18.104.22.168) a serine protease inhibitor, is involved in numerous processes including thrombosis and fibrosis. Its inhibition may thus yield important cardio- and reno-protective benefits. Studies in mice overexpressing human PAI-1 also implicate its involvement in broader biological abnormalities, including alopecia, amyloidosis, and polycystic ovarian syndrome.
 Y. Izuhara et al. A novel inhibitor of plasminogen activator inhibitor-1 provides antithrombotic benefits devoid of bleeding effect in nonhuman primates. J. Cereb. Blood Flow Metab. 2010, 30, 904-912.