Plasminogen activator inhibitor-1 (PAI-1)

Plasminogen activator inhibitor (PAI-1; EC 3.4.21.68) a serine protease inhibitor, is involved in numerous processes including thrombosis and fibrosis. Its inhibition may thus yield important cardio- and reno-protective benefits. Studies in mice overexpressing human PAI-1 also implicate its involvement in broader biological abnormalities, including alopecia, amyloidosis, and polycystic ovarian syndrome[1].


[1] Y. Izuhara et al. A novel inhibitor of plasminogen activator inhibitor-1 provides antithrombotic benefits devoid of bleeding effect in nonhuman primates. J. Cereb. Blood Flow Metab. 2010, 30, 904-912.

4 Item(s)

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Axon ID Name Description From price
1769 T 1776Na Inhibitor of plasminogen activator inhibitor-1 €95.00
1383 Tiplaxtinin Plasminogen activator inhibitor-1 (PAI-1) inhibitor €75.00
2344 TM 5275 Selective and orally active inhibitor of PAI-1 €105.00
2734 TM 5441 Orally active inhibitor of PAI-1  Recently added €95.00

4 Item(s)

per page
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